Electric Literature of 905306-69-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 905306-69-6, name is (5-Methoxypyridin-2-yl)methanamine. This compound has unique chemical properties. The synthetic route is as follows.
To a solution of 1-(5-methoxypyridin-2-yl)methanamine (138 mg, 1 mmol) and 2-chloro-3-methyl-7-(propan-2-yl)imidazo[5,1-f][1,2,4]triazin-4(3H)-one (90 mg, 0.4 mmol) in DMF (1.5 mL) was added DIEA (104 mg, 0.8 mmol). The reaction mixture was stirred at 50C for 10 h and purified by preparative HPLC (MeCN and H2O with 0.01% NH3.H2O as mobile phase) to give the titled compound (40 mg, yield 30 %).LC-MS (m/z) = 329 [M + H]+.1H-NMR (400 MHz, DMSO-d6): delta 1.40 (d, J = 7.2 Hz, 6H), 3.46-3.52 (m, 1H), 3.53 (s, 3H), 3.89 (s, 3H), 4.55 (d, J = 4.0 Hz, 2H), 6.07 (s, 1H), 7.27-7.31 (m, 2H), 7.75 (s, 1H), 8.26 (d, J = 2.4 Hz, 1H).
According to the analysis of related databases, 905306-69-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SUMITOMO DAINIPPON PHARMA CO., LTD.; FUJII, Yuki; FUJIWARA, Hiroaki; KAWASUMI, Muneo; IWAMA, Seiji; IKEDA, Tomoko; KIYOSHIGE, Saori; (219 pag.)WO2016/147659; (2016); A1;,
Pyridine – Wikipedia,
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