Adding a certain compound to certain chemical reactions, such as: 67443-38-3, 5-Bromo-2-chloro-3-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives
Method I: 5-bromo-2-chloro-3-nitropyridine (100 mg, 0.42 mmol) and Ethyl glycolate (0.044 mL, 0.46 mmol) were dissolved in THF (5 mL) and cooled to 0C. Sodium hydride (0.015 mL, 0.46 mmol) was added and the mixture was stirred for 1hr at room temperature. Reaction mixture was poured in ice water and extracted with EtOAc (2 x 10ml). The organiclayer was washed with brine (10ml), dried over sodium sulphate and concentrated. The crude product was purified by flash column using 100-200 silica gel to ethyl 2-(5-bromo-3-nitropyridin-2-yloxy)acetate (105 mg, 82 %) 9(b). 1H NMR (300 MHz, DMSO-d6) delta = 1.27 (s, 3H), 4.25 (q, 2 H), 5.12 (s, 2H) 8.40 (d, J = 2.07 Hz, 1 H), 8.47 (d, J = 2.07 Hz, 1 H); ESMS: m/z 306.8 [M+1]
The synthetic route of 67443-38-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Hameed P., Shahul; Shanbhag, Gajanan; Shinde, Vikas; Chinnapattu, Murugan; Manjrekar, Praveena; Puttur, Jayashree; Patil, Vikas; Ugarkar, Bheemarao; Synthetic Communications; vol. 43; 24; (2013); p. 3315 – 3321;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem