Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 800401-68-7, name is 5-Chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid. A new synthetic method of this compound is introduced below., name: 5-Chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid
To a solution OF 5-CHLORO-LH-PYRROLO [2,3-c] pyridine-2-carboxylic acid (Preparation 18,2. 00g, 10. 2MMOL) IN DMF (SOML) was added L-phenylalanine ethyl ester hydrochloride (2.45g, 10. 7mmol), HOBt (1.37g, 10. 2MMOL) and DIPEA (5.3mL, 30. 5MMOL). After 5MIN, EDCI (2.54g, 13.2mmol) was added and the reaction mixture stirred at rt for 16h. The solvent was removed in vacuo and the solid dissolved in ethyl acetate (150ML) and washed with water (200mL). The organic phase was dried (MGS04), concentrated in vacuo and purified by chromatography on silica gel eluting with METHANOL/DICHLOROMETHANE (3: 97) to give the title compound as a pale yellow solid. ON (CD30D): 1.21 (3H, t), 3.13 (1H, dd), 3. 28 (1H, dd), 4.17 (2H, q), 4.86 (1H, m), 7.09 (1H, s), 7.16-7. 26 (5H, m), 7.65 (1H, s), 8.55 (1H, s); M/Z (ES+) = 372 [M+ H] +.
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Reference:
Patent; OSI PHARMACEUTICALS, INC.; WO2004/104001; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem