With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13534-98-0, name is 4-Amino-3-bromopyridine, molecular formula is C5H5BrN2, molecular weight is 173.01, as common compound, the synthetic route is as follows.HPLC of Formula: C5H5BrN2
To a stirred solution of 3-bromopyridin-4-amine (1.0 g, 5.780 mmol) in dichloromethane (20 mL) was added di isopropyl ethylamine(1.5mL, 8.678mmo1) followed by acetyl chloride(0.45mL, 6.345mmo1) at 0 C and starred at room temperature for 12 h. After completion of the reaction mixture was diluted with dichloromethane (20 mL) and washed with saturated sodium bicarbonate solution (20 mL), dried over sodium sulphate, and concentrated. The crude product obtained as N-(3-bromopyridin-4-yl)acetamide as off white solid.(1 .24 g, 80%).1H NMR (400 MHz, DMSO-d6) oe 3.62 (s, 3H), 6.43 (brs, 2H), 6.77 (d, J= 8.16Hz, 1H), 7.33 (d,J= 2.05Hz, 1H), 7.65 (dd, J= 8.5Hz, 1H)LC-MS m/z (M+H): 215.0
At the same time, in my other blogs, there are other synthetic methods of this type of compound,13534-98-0, 4-Amino-3-bromopyridine, and friends who are interested can also refer to it.
Reference:
Patent; BIOIMICS AB; KIRSEBOM, Leif; UPADHAYAYA, Ram Shankar; KETHIRI, Raghava Reddy; VIRTANEN, Anders; (308 pag.)WO2017/222466; (2017); A1;,
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