Synthetic Route of 7598-35-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7598-35-8, name is 2-Bromopyridin-4-amine. This compound has unique chemical properties. The synthetic route is as follows.
Under the protection of nitrogen, 0.69g (4.00mmol) 2-bromo-4-aminopyridine, 1.02g (6.40mmol) 2, 6-difluoro-3-boronic acid pyridine, 0.28g (0.24mmol) Pd (PPh 3) 4 soluble in 25mLTHF aqueous solution, add 10 ml of the mass fraction of 5% of K 2 CO 3 aqueous solution, heating to 70 C reflux state, the stirring reaction 18h. After the natural cooling to room temperature, adding proper amount of distilled water, many times proper amount of ethyl acetate extraction. Combined with the phase, anhydrous MgSO 4 drying. Filtration, filtrate under reduced pressure, the crude product obtained after evaporating solvent. Using ethyl acetate: hexane (v/v) =1 […] 5 as eluant the separation by silica gel column chromatography, to obtain colourless solid product 0.26g, the yield is 63.0%.
According to the analysis of related databases, 7598-35-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ocean’s king lighting science & technology co. ltd; SHENZHEN OCEAN’S KING LIGHTING SCIENCE & TECHNOLOGY CO., LTD; Zhou, Mingjie; Wang, Ping; Zhang, Juanjuan; Liang, Lusheng; (17 pag.)CN103173209; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem