09/18/21 News Extracurricular laboratory: Synthetic route of 98-98-6

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 98-98-6, Picolinic acid.

Reference of 98-98-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 98-98-6, name is Picolinic acid. This compound has unique chemical properties. The synthetic route is as follows.

To 150 g of thionyl chloride, 38 g of a mixture of 2-pyridinecarboxylic acid hydrochloride and methyl 2-pyridinecarboxylate hydrochloride and 3 g of sodium bromide were added,Slowly warmed to reflux and then maintained at reflux for 16 h. After cooling down to 40 C, 200 g of toluene was added, the thionyl chloride was distilled off under reduced pressure, the temperature was lowered to 10 C, and 50 g of methanol was added dropwise and refluxed for 2 h. And then cooled to 0 C. The filtrate was washed with toluene and suspended in 10 C water. Sodium carbonate was added to precipitate a pale yellow solid. The solid was filtered off, recrystallized from water and dried at room temperature for 18 hours to obtain 25 g of white needle crystals.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 98-98-6, Picolinic acid.

Reference:
Patent; Jinan Chenghui Shuangda Chemical Co., Ltd; Liu, Hao; Meng, de Yong; Wang, Yin; Li, Yuedong; Zhao, hui Qing; (5 pag.)CN105218436; (2016); A;,
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