Adding a certain compound to certain chemical reactions, such as: 6345-27-3, Isonicotinimidamide hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 6345-27-3, blongs to pyridine-derivatives compound. Safety of Isonicotinimidamide hydrochloride
General procedure: The mixture of a chalcone 6a?6i (0.002 mol) in DMSO (5 mL), isonicotinimidamide·HCl (0.003 mol) and potassium carbonate (0.006 mol) was refluxed at 100?110°C for 6?8 h. Upon completion of the reaction, the mixture was poured into ice water and extracted with ethyl acetate. The extract was washed with dil. HCl, 5percent bicarbonate and brine solution. Organic layer was dried over sodium sulfate and concentrated to give a crude product which was purified by column chromatography (hexane : EtOAc =3 : 1). 7-Hydroxy-2,2-dimethyl-6-[6-phenyl-2-(pyridin-4-yl)pyrimidin-4-yl]chroman-4-one (6a). Off white solid, yield 67percent, mp 210?212°C. IR spectrum, nu, cm?1: 1163 (O?C), 1290 (Ar-O), 1552 (C=C), 1579, 1681(C=O), 2964. 1H NMR spectrum, delta, ppm: 14.72 s (1H,Ar-OH), 8.84 br.s (2H, pyridyl-H), 8.58 s (1H, Ar-H),8.27?8.24 m (4H, pyridyl-H, Ar-H), 8.18 s (1H,pyrimidine-H), 7.59 m (3H, Ar-H), 6.54 s (1H, Ar-H),2.76 s (2H, CH2), 1.51 s (6H, 2CH3). 13C NMR spectrum,delta, ppm: 190.81, 167.84, 165.47, 164.57, 163.98,160.32, 150.73, 143.65, 136.09, 131.78, 129.16,127.53, 127.39, 113.86, 112.11, 109.53, 105.94, 80.22,48.98, 26.88. Found, percent: C 73.70; H 4.93; N 9.84. C26H21N33. Calculated, percent: C 73.74; H 5.00; N 9.92. M 424 [M + H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6345-27-3, its application will become more common.
Reference:
Article; Ashok; Kumar, R. Suneel; Mohan Gandhi; Jayashree; Russian Journal of General Chemistry; vol. 86; 6; (2016); p. 1396 – 1404; Zh. Obshch. Khim.; vol. 86; 6; (2016); p. 1396 – 1404,9;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem