Electric Literature of 894074-85-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.894074-85-2, name is Ethyl 2-chloro-5-methylnicotinate, molecular formula is C9H10ClNO2, molecular weight is 199.63, as common compound, the synthetic route is as follows.
A mixture of ethyl 2-chloro-5-methylnicotinate (14.7 g) , 2, 2′ -azobis (isobutyronitrile) (1.31 g) , N- bromosuccinimide (17.1 g) and carbon tetrachloride (200 ml) was heated at 900C for 5 hours. After an aqueous saturated sodium chloride solution (100 ml) was added to the reaction mixture, this was extracted with ethyl acetate, and the ethyl acetate layer was washed with an aqueous saturated sodium chloride solution, dried over magnesium sulfate, and concentrated. The residue was purified by silica gel column chromatography (ethyl acetate-hexane) to obtain the desired product (10.5 g) as an oil. 1H-NMR (CDCl3) delta 1.4 – 1.5 (3H, m) , 4.3-4.5 (4H, m) , 7.97 (IH, d) , 8.19 (IH, d) .
The chemical industry reduces the impact on the environment during synthesis 894074-85-2, I believe this compound will play a more active role in future production and life.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2006/64944; (2006); A1;,
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