09/24/21 News A new synthetic route of 1620-77-5

Statistics shows that 1620-77-5 is playing an increasingly important role. we look forward to future research findings about 5-Methylpicolinonitrile.

Electric Literature of 1620-77-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1620-77-5, name is 5-Methylpicolinonitrile, molecular formula is C7H6N2, molecular weight is 118.14, as common compound, the synthetic route is as follows.

[5-METHYL-PYRIDINE-2-CARBONITRILE] (3.34 g, 28.3 mmol) was mixed with [18] percent HCl (12 ml) and ethanol [(6ML)] and refluxed for 40 h. The reaction mixture was concentrated by rotavapor and the residue was triturated with acetone to give off-white solid 5-methyl-pyridine-2- carboxylic acid hydrochloride. This solid was hydrogenated with [PT02] in ethanol for 2 days until no W active material left. The reaction mixture was filtered, concentrated by vacuum. The residue was triturated with acetone to give 5.3 g of cis and trans 5-methyl- piperidine-2-carboxylic acid hydrochloride as white solid (quantitative).

Statistics shows that 1620-77-5 is playing an increasingly important role. we look forward to future research findings about 5-Methylpicolinonitrile.

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2004/14902; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem