Electric Literature of 115309-58-5, Adding some certain compound to certain chemical reactions, such as: 115309-58-5, name is N-(tert-Butyl)-6-chloronicotinamide,molecular formula is C10H13ClN2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 115309-58-5.
The intermediate A-1 (1.0 g, 4.7 mmol) was dissolved in 15 ml of tetrahydrofuran and the reaction mixture was cooled to 0 C. O-methylphenylmagnesium chloride (1M in tetrahydrofuran solution, 14.1 mL, 14.1 mmol) was slowly added, and the reaction was kept for 3 hours, then heated to 30 C for 18 h, and then cooled to 0 C. Glacial acetic acid (24 mmol) was slowly added dropwise, and then DDQ (dichlorodicyanobenzoquinone or manganese acetate) (1.6 g, 7.1 mmol) was added to react at room temperature for 1 h.The reaction solution was poured into a 2M sodium carbonate solution, extracted with ethyl acetate, washed with water and brine, and dried over anhydrous sodium sulfate.After concentration under reduced pressure, it was purified by silica gel column chromatography.Ethyl acetate/petroleum ether (1:1) was used as the mobile phase to give intermediate A-2.The yield of pale yellow solid was 88%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 115309-58-5, N-(tert-Butyl)-6-chloronicotinamide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Beijing Kuanhou Pharmaceutical Technology Co., Ltd.; Cui Yimin; He Long; Ouyang Liang; Gou Maling; Wang Ling; (39 pag.)CN109384712; (2019); A;,
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