Reference of 139022-25-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.139022-25-6, name is Imidazo[1,2-a]pyridine-6-carboxylic acid, molecular formula is C8H6N2O2, molecular weight is 162.15, as common compound, the synthetic route is as follows.
To a stirred solution of compound D (2.5 g,15.4 mmol, 1 eq) in DMF (50 mL) were added compound E (2.3g, 23.1 mmol, 1.5 eq), triethylamine (15.6 g, 154.3 mmol, 10 eq) and T3P (-50% in ethyl acetate, 14.8 g, 23.1 mmol, 1.5 eq) at 23 C and the resulting mixture was heated at 120 C for 18 h. The reaction mixture was cooled to RT, quenched with water and the organic components were extracted with 10% methanol/ CH2CI2. The organic layer was concentrated in vacuo and the crude material was purified by flash chromatography (Combiflash) using 100-200 mesh silica gel eluting with 10% MeOH/ CH2CI2 to obtain the compound F (600 mg, 20%) as off white solid. (0302) [0292] lH NMR (400 MHz, OMSO-d6) delta 9.03 (s, 1 H), 8.06 (s, 1 H), 7.64 (m, 1 H), 7.59 (d, / = 8 Hz, 1 H), 7.47-7.44 (m, 1 H), 3.61 (s, 3 H), 3.32 (s, 3 H); (0303) [0293] LCMS : m/z = 206.2 [M+H], RT = 0.54 minutes; (Program Rl , Column W).
Statistics shows that 139022-25-6 is playing an increasingly important role. we look forward to future research findings about Imidazo[1,2-a]pyridine-6-carboxylic acid.
Reference:
Patent; ASANA BIOSCIENCES, LLC; THOMPSON, Scott, K.; PRIESTLEY, Tony; KUNDU, Mrinalkanti; SAHA, Ashis; NATH, Suvadeep; (126 pag.)WO2018/64135; (2018); A1;,
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