Application of 1480-87-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1480-87-1, name is 2-Fluoro-3-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows.
Example 32; Protocol for the preparation of terf-butyl 3-(3-(2-(methoxycarbonyl)-3- methylbenzo[b]thiophen-4-ylamino)pyridin-2-yloxy)azetidine-1-carboxylate; a) Preparation of terf-butyl 3-(3-nitropyridin-2-yloxy)azetidine-1-carboxylate; Sodium hydride (60 % dispersion in oil, 2.30 g, 57.64 mmol) was added portionwise into a solution of 1 -Boc-3-(hydroxy)azetidine (9.94 g, 57.64 mmol) in anhydrous THF (110 mL) at 0 C and stirred for 0.5 hour. A solution of 2-fluoro-3-nitro-pyhdine (7.80 g, 54.9 mmol) in anhydrous THF (15 mL) was added drop wise and the mixture allowed to warm to ambient temperature overnight. The mixture was cooled in an ice- bath and water (50 mL) added. The product was extracted with EtOAc, washed with water, brine and dried (Na2SO4). The product was purified by flash- column chromatography (petroleum ether (40-60 0C)/ DCM) to yield the title compound as a yellow solid (4.37 g, 27 %).1H NMR (400 MHz; CDCI3; 25 C): delta 8.36 (m, 1 H), 8.30 (d, 1 H), 7.09 (m, 1 H), 5.45 (m, 1 H), 4.35 (m, 2H), 4.06 (m, 2H), 1.45 (s, 9H). MS (ESI+): 296 (M+H). HPLC (10cm_esci_BICARB): Rt 3.47 min (HPLC purity 93 %).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1480-87-1, 2-Fluoro-3-nitropyridine.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; AUSTEN, Matthias; BLACK, Phillip; BLACKABY, Wesley; DANILEWICZ, John; LINNEY, Ian; SCHREITER, Kay; SCHNEIDER, Martin; WO2010/23181; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem