Related Products of 505084-59-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.505084-59-3, name is 2-Chloro-5-(trifluoromethyl)nicotinic acid, molecular formula is C7H3ClF3NO2, molecular weight is 225.55, as common compound, the synthetic route is as follows.
To a stirred solution of 478 2-chloro-5-(trifluoromethyl)pyridine-3-carboxylic acid (2 g, 8.87 mmol) in 45 THF (5 mL) and 139 MeOH (5 mL) was added 479 (trimethylsilyl)diazomethane (8.87 mL, 17.73 mmol) (2 M in 123 hexane) dropwise at -20 C. and the reaction was stirred at -20 C. for 2 h. The solvent was concentrated under reduced pressure and the residue was purified by flash silica gel chromatography to afford the 480 title compound as an oil. MS (ESI) m/z: 242.2 [M+H+]
The chemical industry reduces the impact on the environment during synthesis 505084-59-3, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Merck Sharp & Dohme Corp.; Han, Yongxin; Achab, Abdelghani; Deng, Yongqi; Fradera, Xavier; Gibeau, Craig; Hopkins, Brett A.; Li, Derun; Liu, Kun; McGowan, Meredeth A.; Sciammetta, Nunzio; Sloman, David; White, Catherine; Zhang, Hongjun; Zhou, Hua; US2019/144433; (2019); A1;,
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