Adding a certain compound to certain chemical reactions, such as: 58757-38-3, 6-Chloronicotinoyl chloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C6H3Cl2NO, blongs to pyridine-derivatives compound. HPLC of Formula: C6H3Cl2NO
Example 23 6-([3-(Cyclopropylmethyl)-2,3,4,5-tetrahydro-1 H-3-benzazepin-7-yl]oxy}-N-methyl-3- pyridinecarboxamide (E23) Step 1: 6-Chloro-N-methyl-3-pyridinecarboxamide; 2M Methylamine in tetrahydrofuran (100 ml, 200 mol) was cooled to 0C and 6- chloronicotinoyl chloride (10.6g, 60 mmol) dissolved in dichloromethane (30 ml) was added dropwise. The solution was stirred to room temperature overnight and concentrated in vacuo. The residue was partitioned between dichloromethane and water, the aqueous phase was extracted with dichloromethane (x3). The combined extracts were washed with water, saturated brine and dried over anhydrous magnesium sulphate. The filtrate was concentrated to a crude solid that was used without further purification. (ES+) m/e 171 [M+H]+.
The synthetic route of 58757-38-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; WO2005/97778; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem