Electric Literature of 7295-76-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7295-76-3, name is 3-Methoxypyridine. This compound has unique chemical properties. The synthetic route is as follows.
(a) To a solution of t-BuLi (216 ml, 1.7M, 0.367 mol) in 1 L of THF at -78 C was added dropwise 1-bromo-2,4,6-trimethyl-benzene (35.6 g, 0.178 mol) over a period of 45 minutes. The mixture was stirred at -78 C. for 1 hour, 3-methoxypyridine (15 g, 0.138 mol) was added and then the mixture was stirred at -23 C. for 3 hours. The above reaction mixture was cooled to -78 C. and 13 g (0.2 mol) of DMF in 25 ml of THF was added and the mixture was stirred for 1 hour. The reaction mixture was quenched with 250 ml of brine, the mixture was stirred overnight, and diluted with 1 L of ether. The aqueous layer was extracted with ethyl acetate (1 L), the combined organic layer was dried over potassium carbonate, and concentrated in vacuo to afford 7.5 g of 3-methoxypyridyl-2-carboxaldehyde.
According to the analysis of related databases, 7295-76-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Sterling Winthrop Inc.; US5554620; (1996); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem