Related Products of 18437-58-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 18437-58-6, name is 4-Amino-2-picoline. This compound has unique chemical properties. The synthetic route is as follows.
To a solution of Intermediate 83B (10 mg, 0.016 mmol) in THF (1 mL) was added2-methylpyridin-4-amine (5.35 mg, 0.049 mmol) and DIEA (0.029 mL, 0.165 mmol) inDCM (1 mL). The mixture was stirred at room temperature for 2 h. TBAF (0.165 mL, 0.165 mmol) was added and the mixture was stirred at room temperature overnight. The reaction was quenched by addition of a small amount of MeOH/water/0. 1% TFA (HPLC solvent). Solvent was removed under vacuum. The residual was dissolved in DMSO andpurified via preparative LC/MS (method D, 30-70% B over 20 mm., then a 5-mm hold at100% B). Fractions containing the desired product were combined and dried via centrifugal evaporation to give Example 85 (0.8 mg, 1.420 imol, 8.60 % yield). ?H NMR (500MHz, DMSO-d6) 8.81 (s, 1H), 8.75 (d, J=1.7 Hz, 1H), 8.35 (d, J5.8 Hz, 1H), 7.95 (s, 1H), 7.50-7.39 (m, 2H), 7.15 (d, J=11.0 Hz, 1H), 5.65 (br. s., 1H), 4.83 (d, J3.6 Hz,2H), 4.71 (br. s., 1H), 4.64 (dd, J=1 1.6, 2.2 Hz, 1H), 4.57-4.44 (m, 2H), 4.31 (dd, J1 1.6,7.2 Hz, 1H), 4.10 (s, 3H), 2.46 (s, 3H). LC-MS: method C, RT = 1.48 mm, MS (ESI) m/z: 564.10 (M+H). Analytical HPLC purity (method B): 100%.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 18437-58-6, 4-Amino-2-picoline.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; ZHANG, Xiaojun; PRIESTLEY, Eldon Scott; HALPERN, Oz Scott; JIANG, Wen; REZNIK, Samuel Kaye; RICHTER, Jeremy M.; (545 pag.)WO2018/13776; (2018); A1;,
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