Reference of 944401-77-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.944401-77-8, name is 2-Amino-4-fluoropyridine, molecular formula is C5H5FN2, molecular weight is 112.105, as common compound, the synthetic route is as follows.
To a solution of 4-fluoropyridin-2-amine (2.5 g, 22.3 mmol) in acetonitrile (25 niL) was added TFA (0.85 mL, 11.16 mmol), S (5.5 g, 24.55 mmol) at 0 C and the reaction mixture was stirred at rt for 4 hours. After completion of the reaction, the reaction mixture was diluted with EtOAc (75 mL). The organic layer was washed with water (20 mL), dried (anhydrous Na
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem