With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13535-01-8, name is 5-Bromopyridin-3-amine, molecular formula is C5H5BrN2, molecular weight is 173.01, as common compound, the synthetic route is as follows.Computed Properties of C5H5BrN2
[0612] To a solution of 3-amino-5-bromo pyridine (XVIII) (1.0 g, 5.78 mmol) in dry pyridine (10 inL) was added pivaloyl chloride (XIX) (769 mg, 6.38 mmol). The reaction mixture was stirred at room temperature for 3 h. The reaction was poured into an ice water/saturated aqueous NaHCC mixture and stirred for 30 min. The precipitate was filtered, washed with cold water and dried at room temperature to yield N-(5-bromopyridin-3-yl)pivalamide (XX) as an off- white solid (1.082 g, 4.22 mmol, 73.1% yield). NMR (OMSO-d6, 500 MHz) delta ppm 1.23 (s, 9H), 8.37 (d, J=2Hz, IH), 8.39 (t, J=2Hz, IH), 8.80 (d, J=2Hz, IH), 9.58 (brs, IH); ESIMS found CioHi3BrN20 mlz 258.9 (Br81M+H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,13535-01-8, 5-Bromopyridin-3-amine, and friends who are interested can also refer to it.
Reference:
Patent; SAMUMED, LLC.; KC, Sunil Kumar; WALLACE, David Mark; CAO, Jianguo; CHIRUTA, Chandramouli; MARAKOVITS, Joseph Timothy; BOLLU, Venkataiah; HOOD, John; (293 pag.)WO2017/23988; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem