The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 18368-57-5, name is 6-Methylpyridine-2-thiol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 18368-57-5
Add 175mL DMF to the 500mL reaction flaskAnd (E)-1-iodo-3-(2,2-diphenyl-vinyl)benzene (38.78 g, 0.102 mol), protected with nitrogen,[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloride dichloromethane complex (1.49 g,0.0018 mol), cesium carbonate (19.8 g, 0.061 mol) and dichloromethane 2 mL, added 5-methyl-pyridine-2-thiol (0.105 mol), heated to 80 C, and reacted for 16 hours until the reaction was complete.Rotate to remove DMF and cool to room temperature.Add 100 mL of ethyl acetate and 150 mL of water.Stir for 40 minutes, separate the organic phase, wash with salt water, layer,The organic phase was dried over sodium sulfate and filtered.Steam to dry,Flash column chromatography gave pale yellow (E)-2-((3-(2,2-diphenyl-vinyl)phenyl)thio)-5-methyl-pyridine, 27.96 g, yield 79% .
With the rapid development of chemical substances, we look forward to future research findings about 18368-57-5.
Reference:
Patent; Hao Huimin; (12 pag.)CN108484485; (2018); A;,
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