The synthetic route of 53937-02-3 has been constantly updated, and we look forward to future research findings.
Related Products of 53937-02-3 , The common heterocyclic compound, 53937-02-3, name is 4-Benzyloxy-2-(1H)-pyridone, molecular formula is C12H11NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A suspension of 4-(benzyloxy)pyridin-2(lH)-one (426 mg, 2.12 mmol), tert-hvXy 7-bromo-9-tosyl-3,4-dihydro-l/f-pyrido[3,4-delta]indole-2(9H)-carboxylate (1.28 g, 2.54 mmol), CuI (484 mg, 2.54 mmol), 8-hydroxyquinoline (369 mg, 2.54 mmol) and Cs2COs (760 mg, 2.33 mmol) in DMSO (10 mL) was degassed under reduced pressure for 45 min. Attorney’s Docket 2882.023BThe suspension was put under Ar and heated at 135 0C with stirring for 1.5 h. The suspension was cooled, 4:1 CH2C12/(9:1 MeOH/NH4OH) (50 niL) was added and the resulting suspension was stirred at 25 0C for 10 min. The suspension was passed through a plug of silica gel and the filtrate was washed with brine. The solution was dried over Na2SO4 and concentrated under reduced pressure to afford an amorphous solid. Flash chromatography (silica gel, (1 :1 EtOAc/hexanes)/(9:0.9:0.1 CH2Cl2/MeOH/NH4OH) 100:0 to 0:100) yielded the title compound (715 mg, 54%) as an off-white solid: 1H NMR (300 MHz, CDCl3) delta 8.18 (br s, IH), 7.82-7.73 (m, 2H), 7.48-7.35 (m, 6H), 7.33-7.23 (m, 4H), 6.12-5.97 (m, 2H) 5.07 (s, 2H), 4.90 (br s, 2H), 3.72-3.64 (m, 2H), 2.73-2.63 (m, 2H), 2.34 (s, 3H), 1.51 (s, 9H).
The synthetic route of 53937-02-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ALBANY MOLECULAR RESEARCH, INC.; WO2009/89482; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem