Reference of 7598-35-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7598-35-8, name is 2-Bromopyridin-4-amine. This compound has unique chemical properties. The synthetic route is as follows.
Et3N (0.64 ml_) and di-tert-butyl dicarbonate (4.62 mmol) at 0 C were added to a solution of commercially available 4-amino-2-bromopyirdine (2.31 mmol, 400 mg) in anhydrous THF (5.9 ml_), and the reaction mixture was stirred overnight at room temperature. The solvent was removed under reduced pressure; then the residue was diluted with EtOAc and sequentially washed with a saturated solution of sodium bicarbonate, water and brine. The organic phase was dried with Na2S04 and concentrated. The crude reaction product was purified by column chromatography over silica gel with a mixture of n- hexane/EtOAc 8:2 as the eluent to afford intermediate O (72% yield). [1H-NMR (CDCIs) d (ppm): 1.52 (s, 9H), 6.68 (bs, 1 H), 7.18 (dd, 1 H, J = 5.6, 2.0 Hz), 7.64 (d, 1 H, J = 1.9 Hz), 8.17 (d, 1 H, J = 5.7 Hz).]
According to the analysis of related databases, 7598-35-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; UNIVERSITA’ DI PISA; CALDERONE, Vincenzo; MINUTOLO, Filippo; TUCCINARDI, Tiziano; TESTAI, Lara; GRANCHI, Carlotta; MARTELLI, Alma; CITI, Valentina; DE LORENZO GARDINAL, Virginia; LENZI, Giulia; LEO, Francesca; MALLOGGI, Giulia; (0 pag.)WO2019/162911; (2019); A1;,
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