10 Sep 2021 News The important role of 14432-12-3

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,14432-12-3, its application will become more common.

Synthetic Route of 14432-12-3 ,Some common heterocyclic compound, 14432-12-3, molecular formula is C5H5ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Preparation 13 : 2-Chloro-5-iodop; Silver sulfate (7.1g, 22.8mmol) and 4-amino-2-chloropyridine (4.06g, 31.6mmol) were added to a solution of iodine (5.65g, 22.3mmol) in ethanol (10OmL) and the reaction mixture stirred at rt for 72h. The bright yellow suspension was filtered, washed with methanol and the filtrate concentrated in vacuo. The residue was partitioned between saturated Na2CO3 solution (20OmL) and EtOAc (200ml). After separation the organic layer was washed with Na2S2O3 solution (5OmL, 25%) and brine (5OmL), dried (MgSO4), concentrated in vacuo and purified by chromatography on silica gel eluting with iso- EPO hexane/EtOAc (3:1 to 2.5:1) to give the title compound, delta? (CDCl3): 4.81 (2H, br s), 6.63 (IH, s), 8.38 (IH, s); m/z (ES+) = 254.86 [M+ H]+; RT = 2.51min.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,14432-12-3, its application will become more common.

Reference:
Patent; PROSIDION LIMITED; WO2006/59164; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem