Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1003-73-2, name is 3-Methylpyridine 1-oxide. A new synthetic method of this compound is introduced below., Application In Synthesis of 3-Methylpyridine 1-oxide
Into the flask, 300 g of methylene chloride and 50 g of 3-picoline-N-oxide were added and the mixture was stirred and cooled to 5C at a constant pressure.A dropping funnel was charged with a mixed solution of 240 g of 2,4,6-triisopropyl-3-benzoyl chloride and 200 g of methylene chloride and slowly added dropwise to the dichloromethane mixture of 3-picoline-N-oxide. In the dropping process, the reaction temperature is controlled at 5 to 10C.The addition was completed within about 3 hours. The reaction was incubated for 2 hours and then warmed to 40C overnight.After the end of the reaction, cool down to 5 ~ 10 C, slowly add 200g of water, after desolvation steam distillation, collecting 100 ~At 102C/760mmHg, the distillate was extracted with methylene chloride. After the aqueous layer was separated, 57.4 g of product was de-solvated.The content of 2-chloro-5-methylpyridine was 98%, 2-chloro-3-methylpyridine was 0.5%, and the yield of 2-chloro-5-methylpyridine was 96.2%.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1003-73-2, 3-Methylpyridine 1-oxide.
Reference:
Patent; Nanjing Hong Sun Biochemical Co., Ltd.; Chen Honglong; Mu Dengyou; Xue Yi; Chen Xinchun; Zhong Jingsong; Wang Fujun; Yang Cheng; (5 pag.)CN107721912; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem