The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 23056-33-9, name is 2-Chloro-4-methyl-5-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2-Chloro-4-methyl-5-nitropyridine
Zinc (15.97 g, 244.0 mmol) was suspended in acetic acid (240 ml) and cooled to 0C. Solid 2-(2-chloro-5-nitropyridin-4-yl)-N,N-dimethylethenamine (5.56 g, 24.42 mmol) was added portion- wise over about 5 minutes and then the reaction mixture was placed under an atmosphere of argon. The reaction was stirred for 18 h, after which time LCMS analysis indicated that the reaction was complete. The mixture was filtered through Celite, washing with EtOAc. The filtrate was concentrated to give a brown oil. The reaction mixture was partitioned between EtOAc and IN NaOH. The aqueous layer was extracted with EtOAc (3x) and the combined organic layer was dried over Na2S04, filtered and concentrated. The residue was adsorbed onto silica gel and purified by flash column chromatography on silica gel, eluting with EtOAc/isohexane (0-100%) to give 2.79 g of an off-white solid, that is approximately a 10: 1 mixture of the title compound along with 5-methoxy-lH-pyrrolo[2,3-c]pyridine as a minor impurity. The mixture was taken forward into the next step as is. LRMS (ESI) calc’d for (C7H5C1N2) [M+H]+, 153; found 153
With the rapid development of chemical substances, we look forward to future research findings about 23056-33-9.
Reference:
Patent; MERCK SHARP & DOHME CORP.; ALTMAN, Michael, D.; FISCHER, Christian; KATZ, Jason, D.; WILLIAMS, Theresa, M.; ZHANG, Xu-Fang; ZHOU, Hua; WO2013/181075; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem