Adding a certain compound to certain chemical reactions, such as: 52605-98-8, 5-Bromo-2,3-dimethoxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C7H8BrNO2, blongs to pyridine-derivatives compound. Computed Properties of C7H8BrNO2
Add 2,3-dimethoxy-5-bromopyridine (218mg, 1.0mmol) to 5mL N, N-dimethylformamide solution, add cuprous cyanide (179.2mg, 4.0mmol), protect with argon Then, the temperature was raised to 160 C, and the reaction was completed after 8 hours of reaction. Cooled to room temperature, diluted with water, extracted with ethyl acetate, washed with saturated brine, dried over anhydrous sodium sulfate, concentrated to remove the solvent, and column chromatography (petroleum ether: ethyl acetate = 10: 1) to obtain the product 2,3- Dimethoxy-5-cyanopyridine (i.e. compound 16, 164.2 mg, 1.0 mmol), white solid, yield 50%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,52605-98-8, 5-Bromo-2,3-dimethoxypyridine, and friends who are interested can also refer to it.
Reference:
Patent; Zhiyuan Pharmaceutical (Qingyuan) Co., Ltd.; Wu Deyan; Xie Ying; Zhou Huifang; (24 pag.)CN110498784; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem