13 Sep 2021 News Sources of common compounds: 6980-08-1

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6980-08-1, 4-Chloro-3-nitropyridin-2-amine, other downstream synthetic routes, hurry up and to see.

Related Products of 6980-08-1, Adding some certain compound to certain chemical reactions, such as: 6980-08-1, name is 4-Chloro-3-nitropyridin-2-amine,molecular formula is C5H4ClN3O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6980-08-1.

To 400 mg (2.32 mmol) of 5-N-BOC-amino-8-hydroxy-quinoline dissolved in 30 mL DMF (dry), were added under stirring and argon atmosphere, 360 mg (3.20 mmol) tert-BuOK. After 30 minutes, 400 mg (2.32 mmol) 2-amino-3-nitro-4-chloropyridine were added at once and the reaction mixture heated at 850C (bath) for 5 hours. After cooling, 200 mL AcOEt were added and the solution extracted with 2 x 200 mL brine. The solution was dried (MgSO4) and evaporated under vacuum. The residue was purified on an lsolute column (Flash Si II; 50 g, 170 mL) eluted with AcOEt. The title compound was obtained as a yellow solid: 0.534 g. Yield: 58%. 1H NMR (500 MHz, DMSO-d6) delta: 1.51 (s, 9H, C(CH3J3), 5.65 (d, 1 H, HPyr, J=5.6 Hz), 7.14 (S, 2H1 NH2), 7.58-7.61 (m, 1 H1 HArom), 7.64 (d, 1 H, HArom, J= 8.3 Hz), 7.74 (d, 1 H, HArom, J= 8.3 Hz), 7.82 (d, 1 H, HPyr), 8.53-8.55 (m, 1H, Harom), 8.84-8.86 (m, 1H, Harom), 9.51 (S, 1 H, NH); LC-MS, tR = 6.51 min, m/z: 397.1 (M)+, calcd for C19H19N5O5.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6980-08-1, 4-Chloro-3-nitropyridin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE); WO2009/130487; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem