Related Products of 586-95-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.586-95-8, name is 4-Pyridinemethanol, molecular formula is C6H7NO, molecular weight is 109.13, as common compound, the synthetic route is as follows.
(l-Benzyl-l,2,3,6-tetrahydropyridin-4-yl)methanol. 4-Hydroxymethyl- pyridine (20 g, 183 mmol, 1.0 eq) was dissolved in DMF (80 mL) andbenzylbromide (24.2 mL; 202 mmol) was added and the solution was stirred at 100 C for 2 hours. The solution was allowed to cool to RT and diluted with EtOH (300 mL) and treated portionwise with NaBH4 (8.7 g; 230 mmol) and stirred at reflux for 3 hours. The solution was allowed to cool to RT and concentrated largely. The residue was taken up in EtOAc and water and the organic phase was dried (Na2S04), filtered and concentrated to give 35 g crude oil. The material was purified with a short plug (10 cm) of silica eluting with EtOAc to give the product (23.9 g; 64%) which was isolated as an oil. NMR (300 MHz, CDC13) delta ppm 7.39-7.2 (m, 5H), 5.69-5.63 (m, 1H), 4.03 (s, 2H), 3.58 (s, 2H), 3.0 (m, 2H), 2.6 (t, J= 6 Hz, 2H), 2.21-2.11 (m, 2H).
Statistics shows that 586-95-8 is playing an increasingly important role. we look forward to future research findings about 4-Pyridinemethanol.
Reference:
Patent; ABBOTT HEALTHCARE PRODUCTS B.V.; STOIT, Axel; IWEMA BAKKER, Wouter, I.; COOLEN, Hein K.A.C.; VAN DONGEN, Maria J.P.; LEFLEMME, Nicolas J.-L.D.; WO2012/4378; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem