Synthetic Route of 70201-42-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.70201-42-2, name is 3,5-Dibromoisonicotinaldehyde, molecular formula is C6H3Br2NO, molecular weight is 264.9, as common compound, the synthetic route is as follows.
To a solution of cesium carbonate (9.20 g, 28.2 mmol) and 4-phenylphenol (2.40 g, 14.1 mmol) in anhydrous THF (100 mL) under an inert atmosphere was added a solution of 3,5-dibromopyridine-4-carboxaldehyde (7.48 g, 28.2 mmol) in THF (25 mL). The reaction mixture was heated at reflux for 4 hours then was allowed to cool to room temperature. The reaction mixture was filtered and the solvent was removed in vacuo. The residue was diluted with EtOAc, washed with aqueous sodium bicarbonate, washed with brine, and dried over sodium sulfate then filtered and the solvent removed in vacuo. Purification by silica gel (eluting with 20% EtOAc: heptane) followed by recrystallization from heptane afforded 3- (bipfienyl-4-yloxy )-5-bronio-pyridine-4-carbaldehyde (4.39 g, 12.4 mmol, 87%); (at)H-NMR (DMSO-d6, 400 MHz) : 8 7.23 (m, 2H), 7.38 (m, 1H), 7.47 (m, 2H), 7.66 (m, 2H), 7.73 (m, 2H), 8.43 (s, 1H). RP-HPLC (Table 1, Method i) R(at) = 3.72 min.
Statistics shows that 70201-42-2 is playing an increasingly important role. we look forward to future research findings about 3,5-Dibromoisonicotinaldehyde.
Reference:
Patent; ABBOTT LABORATORIES; WO2005/110410; (2005); A2;,
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