Application of 6332-56-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6332-56-5, name is 3-Nitropyridin-2(1H)-one, molecular formula is C5H4N2O3, molecular weight is 140.1, as common compound, the synthetic route is as follows.
a)Preparation of 2-amino-3-hydroxypyridine To a solution of 2-hydroxy-3-nitropyridine (5 g, 45.4 mmol) in methanol(250 ml) was added 10% Pd/C (1 g). The mixture was flushed with argon, then hydrogen was bubbled through the solution for 10 min. and a hydrogen atmosphere was maintained at balloon pressure overnight. The mixture was filtered through celite and the celite was washed with methanol. The solvent was evaporated and chromatography of the resulting solid on silica gel (5% MeOH/CH2Cl2) gave the desired product(3.2 g, 89%). 1H NMR (CD3OD): delta 6.96 (d, 1H), 6.90 (dd, 1H), 6.77 (d, 1H).
Statistics shows that 6332-56-5 is playing an increasingly important role. we look forward to future research findings about 3-Nitropyridin-2(1H)-one.
Reference:
Patent; SmithKline Beecham Corporation; US6218539; (2001); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem