Adding a certain compound to certain chemical reactions, such as: 100-48-1, Isonicotinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 100-48-1, blongs to pyridine-derivatives compound. COA of Formula: C6H4N2
General procedure: 0.01mol nitrile dissolved in 10 ml ethanol. After that, 0.011 mol hydroxylamine hydrochloride, 10 ml water and 1.23g sodium acetate was added as followed, stirred in room temperature for 0.5 h then refluxed in 50-60 for 8 h. The ethanol was mostly evaporated in vacuum and then the aqueous residue was extracted with CH2Cl2 three times. The combined organic layer was dried over MgSO4 and evaporated to dryness to afford the desired product.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,100-48-1, its application will become more common.
Reference:
Article; Su, Dongshan; Duan, Haifeng; Wei, Zhonglin; Cao, Jungang; Liang, Dapeng; Lin, Yingjie; Tetrahedron Letters; vol. 54; 50; (2013); p. 6959 – 6963;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem