Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 603305-89-1, name is 7-Bromothieno[3,2-b]pyridine. A new synthetic method of this compound is introduced below., COA of Formula: C7H4BrNS
General procedure: Compound N13z (24.45 mg, 0.118 mmol) in 1,4-dioxane (2 ml) was added Pd2(dba)3 (10.76 mg, 0.012 mmol), XantPhos (13.6 mg, 0.0235 mmol), 4-bromoquinoline (50 mg, 0.118 mmol), and DIPEA (61.4 muL, 0.353 mmol). The reaction vessel was degassed with argon, sealed, and heated to 110 C. overnight. The reaction mixture was then cooled to room temperature, filtered through Celite, and concentrated. The resulting residue was concentrated, diluted with 1:1 acetonitrile and water each containing 0.1% TFA and purified on preparatory HPLC (0 to 100% acetonitrile in water each containing 0.1% TFA). This provided Compound E78a as a TFA salt. LCMS ESI+ calc’d for C29H34N6O2S: 531.3 [M+H+]. found: 531.2 [M+H+].
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Reference:
Patent; Gilead Sciences, Inc.; Chin, Gregory; Clarke, Michael O’ Neil Hanrahan; Han, Xiaochun; Hansen, Tim; Hu, Yunfeng Eric; Koltun, Dmitry; McFadden, Ryan; Mish, Michael R.; Parkhill, Eric Q.; Sperandio, David; Xu, Lianhong; Yang, Hai; (199 pag.)US2020/108071; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem