Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 88912-21-4, name is 6-Chloro-4-methoxypicolinic acid. A new synthetic method of this compound is introduced below., Application In Synthesis of 6-Chloro-4-methoxypicolinic acid
Synthesis Example 19 Synthesis of N-[(2,6-Difluorophenyl)sulfonyl]-6-chloro-4-methoxy-2-pyridinecarboxamide [Compound (I-975)] Using 2,6-difluorobenzenesulfonamide [Compound (III-14)] (0.309 g, 1.6 mmol) and 6-chloro-4-methoxypicolinic acid [Compound (II-75)] (0.3 g, 1.6 mmol), the Compound (I-975) was synthesised according to the process of Synthesis Example 3. White solid, yield: 0.3129 g, percent yield: 54.0%, m.p.: 160-163 C. IR KBr cm-1: 3262, 1725, 1620, 1434, 1398, 1317, 1188, 1029, 891, 642. 1H-NMR (60 MHz, CDCl3, 6): 3.8 (3H, s, OCH3), 6.7-7.5 (4H, m, aromatic ring H*3, pyridine ring H), 7.43 (1H, d, J=2 Hz, pyridine ring H), NH indistinctness.
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Reference:
Patent; Kureha Kagaku Kogyo K.K.; US6610853; (2003); B1;,
Pyridine – Wikipedia,
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