The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 58483-95-7, name is 5-Amino-2-chloropyridine-4-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives
General procedure: A mixture of compound 5-amino-2-chloropyridine-4-carboxylic acid(1000 g, 5.8 mol) was dissolved in 5000 mlEthylene glycol monomethyl ether, AddedFormamidine hydrochloride(1867 g, 23.2 mol), sodium acetate (2360 g, 17.4 mol). The reaction was heated to 120 ° C for 6 hours. After the reaction was complete, the reaction was cooled to room temperature, poured into 4000 ml of water and extracted twice with ethyl acetate. The organic phase was combined, dried and concentrated to afford the crude product which was filtered to give 6-chloropyridine And [3,4-d] pyrimidin-4 (3H) ketone (924 g, 5-1 mol)
With the rapid development of chemical substances, we look forward to future research findings about 58483-95-7.
Reference:
Patent; Bide Pharmatech Ltd.; Li, Jinfei; Li, Xinling; Huang, Liangfu; Ou, Yanghao; (7 pag.)CN104130256; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem