17-Sep News Analyzing the synthesis route of 53937-02-3

Adding a certain compound to certain chemical reactions, such as: 53937-02-3, 4-Benzyloxy-2-(1H)-pyridone, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 53937-02-3, blongs to pyridine-derivatives compound. Application In Synthesis of 4-Benzyloxy-2-(1H)-pyridone

A. Preparation of the intermediate compounds; Al. Preparation of intermediate compound 1-1; To a solution of 4-benzyloxy-2(lH)-pyridone (2 g, 10.0 mmol) in DCM (20 ml), was added 4-bromophenylboronic acid (4 g, 24.0 mmol), Cu(OAc)2 (0.360 g, 2.0 mmol), pyridine (1.51 ml, 20.0 mmol), TEMPO (1.72 g, 11 mmol) and molecular sieves (4 A) (2 g). The reaction mixture was stirred overnight at room temperature. The solid was filtered off. The filtrate was treated with an aqueous solution of NH4OH. The organic layer was separated, dried (Na2SO4) and the solvent evaporated. The resulting residue was purified by column chromatography (DCM 100 to DCM/EtOAc 4/1). The desired fractions were collected and the solvent was evaporated. The residue was treated with DIPE to yield intermediate compound 1-1 (3.16 g, 89 %).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,53937-02-3, its application will become more common.

Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2007/141200; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem