Adding a certain compound to certain chemical reactions, such as: 1174229-72-1, Ethyl 2-(6-aminopyridin-3-yl)acetate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1174229-72-1, blongs to pyridine-derivatives compound. Recommanded Product: 1174229-72-1
A 20-mL vial was charged with 4-chloro-2-(3-chlorophenyl)-6- cyclopropylpyrimidine (0.380 g, 1.43 mmol), ethyl 2-(6-aminopyridin-3-yl)acetate (0.410 g, 2.27 mmol), palladium acetate (0.016 g, 0.071 mmol), rac-BINAP (0.069 g, 0.11 mmol) and cesium carbonate (1.17 g, 3.58 mmol) in dioxane (10 mL) under argon. The reaction mixture was heated to 110 C under microwave irradiation for 1.25 h. The reaction mixture was cooled, and diluted with ethyl acetate and filtered through celite. The filtrate was washed with saturated sodium chloride (2 x 10 mL), dried over sodium sulfate, filtered, and the filtrate concentrated under reduced pressure. The residue was purified by chromatography on silica using hexanes/ethyl acetate (10:0 to 0: 10) as eluent to afford the title compound (0.504 g, 86%) as an off-white solid. MW = 408.88. M.p. 133-135 C. ]H NMR (DMSO- , 500 MHz) delta 10.13 (s, 1H), 8.31-8.29 (m, 1H), 8.27 (dt, / = 7.0, 1.5 Hz, 1H), 8.22 (d, / = 2.0 Hz, 1H), 7.75-7.68 (m, 2H), 7.62 (br s, 1H), 7.59-7.52 (m, 2H), 4.10 (q, / = 7.5 Hz, 2H), 3.68 (s, 2H), 2.07 (septet, / = 4.5 Hz, 1H), 1.21 (t, / = 7.0 Hz, 3H), 1.14-1.10 (m, 2H), 1.06-1.00 (m, 2H); APCI MS m/z 409 [M+H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1174229-72-1, its application will become more common.
Reference:
Patent; TETRA DISCOVERY PARTNERS, LLC.; GURNEY, Mark, E.; HAGEN, Timothy, J.; MO, Xuesheng; VELLEKOOP, A.; ROMERO, Donna, L.; CAMPBELL, Robert, F.; WALKER, Joel, R.; ZHU, Lei; WO2014/66659; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem