As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100866-13-5, name is 2-(Pyridin-4-yl)-1-(p-tolyl)ethanone, molecular formula is C14H13NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C14H13NO
General procedure: To the intermediate ketone product (10 mmol) dissolved in MeOH (1 M) was addedhydroxylamine hydrochloride (1.04 g, 15 mmol, 1.5 equiv.) and NaOMe (0.81 g, 15 mmol,1.5 equiv.). This suspension is stirred at room temperature for 8 h until complete conversionof the substrate into the desired oxime is achieved (monitored by tlc and/or 1H-NMR).Aqueous extraction (3 × DCM/water) followed by drying the combined organic layers oversodium sulfate, filtration and evaporation to yield the oxime products as solids or oils thatsolidify upon storage.
With the rapid development of chemical substances, we look forward to future research findings about 100866-13-5.
Reference:
Article; Baumann, Marcus; Baxendale, Ian R.; Synlett; vol. 27; 1; (2016); p. 159 – 163;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem