Adding a certain compound to certain chemical reactions, such as: 1263280-06-3, 5-Bromo-3,3-dimethyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 5-Bromo-3,3-dimethyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one, blongs to pyridine-derivatives compound. Recommanded Product: 5-Bromo-3,3-dimethyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one
To a stirred solution of compound I (0.050 g, 0.207 mmol ) in propionitrile (4 ml) and DMF (1 ml) were added compound B( 0.047 g,0.207 mmol ),Pd(OAc)2( 0.004 g,0.0207 mmol ), P(o-tol)3 (0.011 g, 0.04 mmol )and DIPEA (0.053g, 0.4mm01 ) .The total reaction mass was purged with argon and heated at reflux temperature for 16 h. Reaction mass cooled to room temperature and concentrated under vacuum. Crude reaction mass was purified by column chromatography by eluting with 60% ethyl acetate in pet ether to afford the desired compound VT-02-00066 (0.017g). ? NMR (400 MHz, CDC13) 8.5 (s,lH ), 8.28(s,lH ), 7.6-7.63(d, J=1.2 Hz ,1H ),7.6(s,lH), 7.5(d, J= 8.0 Hz ,1H ) , 7.42 (d, J= 8.0Hz ,1H), 7.3 (m,2H), 6.85 (d, J= 2.0Hz ,1H ), 3.2 (d, J= 4.4Hz ,3H ), 1.44 (s,6H). MS(ESI): m/z 392(M+H)+
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1263280-06-3, 5-Bromo-3,3-dimethyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one, and friends who are interested can also refer to it.
Reference:
Patent; VITAS PHARMA RESEARCH PRIVATE LIMITED; RANGARAJAN, Radha; KUMAR, Rajinder; PRABHAKAR, B V; CHANDRASEKHAR, P; MALLIKARJUNA, P; BANERJEE, Ankita; WO2013/42035; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem