Application of 5470-18-8, Adding some certain compound to certain chemical reactions, such as: 5470-18-8, name is 2-Chloro-3-nitropyridine,molecular formula is C5H3ClN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5470-18-8.
A 5 L round bottom flask fitted with a condenser, mechanical stirrer and a nitrogen inlet was charged with 152.3 g (0.96 mol) of 2-chloro-3-nitropyridine and 1.65 L of 1,2-dimethoxyethane. The solution was degassed by bubbling nitrgen through the solution for 10 min and 56.7 g (0.49 mol, 0.05 equiv) of tetrakis (tliphenylphosphine)-palladium (0) was added. The mixture was degassed for an additional 45 min during which time the catalyst dissolved leaving a clear dark red solution. A degassed solution of 180.3 g (1.48 mol, 1.54 equiv) of phenylboronic acid in 800 [ML] of absolute ethanol was added followed by 1.65 L of degassed 2M aqueous sodium carbonate solution. The cloudy mixture was heated to reflux, and refluxed for 1.5 h. While at reflux a yellow suspension formed. The suspension was cooled to ambient temperature, diluted with 1 L of ethyl acetate, and filtered through [CELITE THE] cake was washed with 2 L of ethyl acetate and the filtrate washed with water (2 x 3 L), saturated sodium bicarbonate solution [(1 X 3] L), and saturated sodium chloride solution (1 x 3 L). The organic layer was dried with magnesium sulfate, filtered and the filtrate concentrated. The residue was dissolved in 1.5 L of ether, washed with 2.5N [NAOH] (2 x 500 mL) and brine (500 mL). The solution was dried with magnesium sulfate, filtered through 400 g of silica and the cake washed with additional ethyl acetate. The filtrate was concentrated to an oil which was chromatographed [5 kg Silica Gel 60,70-230 mesh, hexanes/ethyl acetate 80: 20 (12 L), 75: 25 (8 L), 70: 30 (11 L) and 60: 40 (7 L) ]. The product fractions were concentrated yielding 188.0 g (97% yield) of the title compound 2-phenyl-3-nitropyridine, as a pale yellow oil: [IH] NMR [(CDCL3)] 8 7.39-7. 49 (m, [4H),] 753-7.95 (m, 2H), 8.12 (m, 1H) 8.84 (m, [1H).] MS [(EI)] [M/Z] 200. Anal. Calcd for [CLLH8N204] : C, 66.00 ; H, 4.03 ; N, 13.99. Found: C, 66.19 ; H, 4.09 ; N, 13.98.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5470-18-8, 2-Chloro-3-nitropyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK & CO., INC.; WO2004/29024; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem