Application of 24484-93-3, Adding some certain compound to certain chemical reactions, such as: 24484-93-3, name is Methyl 4-chloropicolinate,molecular formula is C7H6ClNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 24484-93-3.
Preparation of 4-chloro-N-(methyl-d3)picolinamide A2 To a three-necked bottom flask with tetrahydrofuran (250 mL), methyl 4-chloro-2-picolinate (50 g, 291 mmol, 1 eq) was added. N-(methyl-d3)amine hydrochloride (31 g, 437 mmol, 1.5 eq) and anhydrous potassium carbonate(400-mesh, 80 g, 583 mmol, 2 eq) were added with stirring. After the mixture was stirred at room temperature for 20 h, water (250 mL) and methyl tert-butyl ether (150 mL) were added. The mixture was stirred and separated. The aqueous layer was extracted with methyl tert-butyl ether (100 mL). The organic phases were combined, dried over anhydrous sodium sulfate and filtered. The solvent in the filtrate was removed under reduced pressure to obtain the product (48 g, purity 99%, yield 96%) as light yellow liquid. 1H NMR(DMSO-d6, 400 MHz): delta7.64(dd, J = 2Hz, 5.2Hz, 1H), 7.97(d, J = 1.6Hz, 1H), 8.54(d, J = 5.2Hz, 1H), 8.74(br, 1H). MS (ESI, m/z) calcd. for C7H4D3ClN2O: 173, found : 174 [M +H]+
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 24484-93-3, Methyl 4-chloropicolinate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Suzhou Zelgen Biopharmaceutical Co., Ltd.; FENG, Weidong; GAO, Xiaoyong; DAI, Xiaojun; EP2548867; (2013); A1;,
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