Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 56026-36-9, name is Methyl 6-(hydroxymethyl)nicotinate. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: Methyl 6-(hydroxymethyl)nicotinate
Step 1.; Preparation of methyl 6-((methylsulfonyloxy)methyl)nicotinate; [0121] A Catalytic amount of DMPA (dimethylol propionic acid), triethylamine (2.Og, 19.7mmol) in 20 mL CH2C12, and methanesulfonyl chloride (1.95g, 17.0mmol) are added dropwise to a solution of 6-hydroxymethyl-nicotinic methyl ester 6 (2.2g, 13.1mmol), at -78C under argon. The mixture is stirred for 5 hours at -78C and then quenched with 30 mL saturated aqueous sodium bicarbonate. The organic layer is collected and the water phase extracted with CH2C12 (2x30mL). The organic phases are combined and washed with water. The CH2C12 solution is dried over MgSO4 and concentrated to give compound 7, which is used without further purification.
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Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WO2006/122011; (2006); A2;,
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