Day: November 6, 2020

74115-13-2, A common compound: 74115-13-2, name is 5-Bromo-3-pyridinol,molecular formula is C5H4BrNO, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

To a solution of 5-bromopyridin-3-ol (L) (174 mg, 1.0 mmol) in DMF (3 mL) was added potassium carbonate (415 mg, 3.0 mmol). The slurry was heated at 90C for 1 h and then cooled to 25 C. The (bromomethyl)benzene (LIV) (171 mg, 1.0 mmol) was added and the mixture was stirred at 25C overnight. The reaction was worked-up using a saturated sodium bicarbonate and EtOAc extraction. The product was purified by ISCO column (40-100% EtOAc- hexanes). The 3-(benzyloxy)-5-bromopyridine (LV) (105 mg, 0.398 mmol, 39.8 % yield) was obtained as yellow oil. ESIMS found for Ci2Hi0BrNO mlz 266.1 (M+H).

With the rapid development of chemical substances, we look forward to future research findings about 74115-13-2.

Reference:
Patent; SAMUMED, LLC; KC, Sunil Kumar; WALLACE, David Mark; CAO, Jianguo; CHIRUTA, Chandramouli; HOOD, John; (251 pag.)WO2017/24003; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

100-26-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 100-26-5, name is 2,5-Pyridinedicarboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Three series of [Ln2(pydc)2(SO4) (H2O)x]yH2O (x= 0, 2, 3; y= 0, 2,6), differing in numbers of the coordinated (x) and the crystallizing (y) water molecules, were hydrothermally synthesized through subtlealteration in reaction temperature and time (Scheme 1). [Ln2(pydc)2(SO4) (H2O)2]6H2O; LnLa (Ia), Pr (Ib), Nd (Ic). To synthesize Ia, a solution of La2(SO4)38H2O (0.1420 g, 0.2000 mmol) and H2pydc (0.0334 g, 0.200 mmol) was prepared using 10.00 ml of deionized water, into which 50.0 muL triethylamine was added to adjust pH of the solution to 5. The solution was then transferred into a 23mL Teflon lined hydrothermal reactor, which was then sealed and heated at two different temperatures, i.e. 80 and 120 C, for 1 day. After the reaction was cooled down to room temperature, colorless block crystals of Ia was obtained in ca. 35% yield based on LaIII.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 100-26-5, 2,5-Pyridinedicarboxylic acid.

Reference:
Article; Sinchow; Chuasaard, Thammanoon; Yotnoi, Bunlawee; Rujiwatra, Apinpus; Journal of Solid State Chemistry; vol. 278; (2019);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

766-11-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 766-11-0, name is 5-Bromo-2-fluoropyridine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of alcohol 1a-r or benzyl mercaptan 1s (1.5 equiv.) in anhydrous THF (100 mL) was slowly added 60% sodium hydride (2.0 equiv.). The mixture was allowed to react at room temperature for 30 min then it was heated to reflux for 1 h. 5-bromo-2-fluoropyridine (1 equiv.) was added and the reaction was continued for 12 h. After cooling down to room temperature, the mixture was poured into water and extracted with ethyl acetate. The organic phase was washed with brine, dried on MgSO4, filtered, evaporated and purified by silica gel chromatography.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 766-11-0, 5-Bromo-2-fluoropyridine.

Reference:
Article; Fontaine, Fanny; Hequet, Arnaud; Voisin-Chiret, Anne-Sophie; Bouillon, Alexandre; Lesnard, Aurelien; Cresteil, Thierry; Jolivalt, Claude; Rault, Sylvain; European Journal of Medicinal Chemistry; vol. 95; (2015); p. 185 – 198;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7379-35-3, name is 4-Chloropyridine hydrochloride. A new synthetic method of this compound is introduced below., 7379-35-3

N-t-butoxycarbonyloxy 2- (piperidin-4-yl)-ethylamine (prepared per Method K’above) (14.4 g, 50 mmol), 4-chloropyridine HC1 (1.0 eq. , 8.0 g), TEA (2.2 eq. ) were mixed in ethanol, and maintained under reflux overnight. The desired compound, N-t-butoxycarbonyloxy 2- [1- (pyrid-4-yl) piperidin-4-yl] – ethylamine, was isolated by column chromato-graphy, (silica gel) eluted with EtOAc and carried in the next step.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7379-35-3, 4-Chloropyridine hydrochloride, and friends who are interested can also refer to it.

Reference:
Patent; ELAN PHARMACEUTICALS, INC.; WO2003/93245; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

5470-18-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5470-18-8, name is 2-Chloro-3-nitropyridine, molecular formula is C5H3ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 1 : A mixture of 2-chloro-3-nitropyridine (5.0 g, 31.5 mmol) and aniline (5.8 mL, 63.1 mmol) was heated to 140C for 90 minutes. After cooling to ambient temperature, the mixture was diluted with water (200 mL) and extracted with three portions (50 mL each) of dichloromethane. The combined extracts were dried over anhydrous magnesium sulfate, filtered, and concentrated in vacuo. The crude solids were recrystallized from isopropyl alcohol to afford 3.50 g of 3-nitro-N-phenylpyridin-2-amine.HRMS: calculated for C11H9N3O2 + H+, 216.07675; found (ESI, [M+H]+), 216.0787HPLC purity 100.0% at 210-370 nm, 9.5 minutes.; Xterra RP18, 3.5u, 150 x 4.6 mm column,1.2 mL/min, 85/15-5/95 (ammonium formate buffer pH=3.5, acetonitrile/MeOH) for 10 minutes, hold 4 minutes.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5470-18-8, 2-Chloro-3-nitropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; WYETH; WO2008/73459; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

74115-13-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 74115-13-2, name is 5-Bromo-3-pyridinol, molecular formula is C5H4BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of 5-bromopyridin-3-ol (1.0 eq.), benzyl bromide (1.2 eq.), and silver carbonate (1.3 eq.) in toluene (0.1 M) was heated to 50 C. and stirred for 18 hours. After cooling to room temperature, the reaction mixture was filtered, eluting with ethyl acetate. The filtrate was concentrated en vacuo into a residue that was purified by a COMBIFLASH system (ISCO) using 20% ethyl acetate in hexane to give 3-(benzyloxy)-5-bromopyridine.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 74115-13-2, 5-Bromo-3-pyridinol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GlaxoSmithKline Biologicals SA; Skibinski, David; Jain, Siddhartha; Singh, Manmohan; O’Hagan, Derek; (124 pag.)US9408907; (2016); B2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 142-08-5, name is Pyridin-2(1H)-one. A new synthetic method of this compound is introduced below., 142-08-5

General procedure: To a stirred solution of substituted or unsubstituted 2-pyridone (1 eqiv) in acetic acid (10 ml) was added N-halosuccinamide (1.5 eqiv) and heated to 120 C overnight. The recation mixture was flitered,concentrated, diluted with saturated aqueous NaHCO3 and extracted twice with ethyl acetate. The combined ethyl acetate layers were washed with brine, dried over anhydrous sodium sulfate, filtered,concentrated and purified by combiflash to give C in good to excellent yields.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,142-08-5, Pyridin-2(1H)-one, and friends who are interested can also refer to it.

Reference:
Patent; PI INDUSTRIES LTD.; SHANBHAG, Gajanan; DODDA, Ranga Prasad; KAMBLE, Ganesh Tatya; KALE, Yuvraj Navanath; RENUGADEVI, G.; MANJUNATHA, Sulur G; S.P., Mohan Kumar; AUTKAR, Santosh Shridhar; GARG, Ruchi; VENKATESHA, Hagalavadi M; MAVINAHALLI, Jagadeesh Nanjegowda; KLAUSENER, Alexander G.M.; (161 pag.)WO2018/193387; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

98-98-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 98-98-6, name is Picolinic acid, molecular formula is C6H5NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

5. Methyl 4-chloropicolinate; A mixture of picolinic acid (15 g, 122 mmol) sodium bromide (1.88 g, 18.3 mmol), and thionyl chloride (45 mL) is heated to reflux and stirred for 20 h. After cooling to rt, the excess thionyl chloride is removed in vacuo. The resulting residue is taken up in toluene (100 mL) and cooled to 0 0C. MeOH (7 mL) is added dropwise, after which time the reaction is warmed to rt and stirred an additional 1.5 h. The precipitated solid is collected by filtration, washed with toluene, and partitioned between EtOAc (200 mL) and water (100 mL). The mixture is neutralized to pH=7-8 with solid NaHCO3. The EtOAc layer is dried (Na2SO4), filtered, and evaporated in vacuo to give the title compound as a light brown solid. MS: 171.94 (M+H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 98-98-6, Picolinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NEUROGEN CORPORATION; WO2008/70014; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

1121-60-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1121-60-4, name is Picolinaldehyde, molecular formula is C6H5NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A mixture of aldehyde (1mmol) and o-phenylenediamine 1a (1mmol, 108.1 mg) in water (1 mL) were added to dispersed solution of GO (100 wt%, 108.7 mg) in water (2 mL) and the reaction mixture was stirred at 60 C forappropriate time (Table 2). After completion of the reaction(monitored by TLC using n-hexane/EtOAc 9:1 as eluent), theGO was separated by filtration and the solution was extractedwith ethyl acetate (2 5 mL). The GO was washed with warmethanol (about 75 C, 5 10 mL) and then organic layers(EtOAc and ethanol) were combined and dried over anhydroussodium sulfate. The solvents were removed under reducedpressure and the residue left out was purified by chromatographyon a short column of silica gel eluted with n-hexane/ethyl acetate (9:1) to give the corresponding benzimidazoles 2in 78-95%yield (Table 2).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1121-60-4, Picolinaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Khalili, Dariush; Banazadeh, Ali Reza; Bulletin of the Chemical Society of Japan; vol. 88; 12; (2015); p. 1693 – 1706;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

4926-28-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4926-28-7, name is 2-Bromo-4-methylpyridine, molecular formula is C6H6BrN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 20; Synthesis of 2-bromoisonicotinic acid; [0119] 2-Bromo-4-methylpyridine (10 g, 0.058 moles) and potassium permanganate (18.3 g, 0.115 moles) was combined in water (500 ml). The mixture was refluxed for five hours, filtered through celite and reduced in volume to-400 ml. The dark brown solution was acidified with hydrochloric acid (10%) to pH-3. The resulting white precipitate was filtered and rinsed with ethyl ether. 2-Bromoisonicotinic acid was isolated in 34 % yield. 1H NMR (DMSO-d6) 7.8 (1H, d), 7.85 (1H, s), 8.5 (1H, d).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 4926-28-7, 2-Bromo-4-methylpyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; DOV PHARMACEUTICAL, INC.; WO2005/84439; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem