Day: December 3, 2020

5470-70-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5470-70-2, name is Methyl 6-methylnicotinate. This compound has unique chemical properties. The synthetic route is as follows.

Step 1: PtO2 (3.00 g) was added to a methanol solution (200 mL) of methyl 6-methylpyridine-3-carboxylate(18.00g, 119.08 mmol), and then added with water (10mL) and hydrochloric acid (20mL); under H2 (50psi), the reaction solutionwas heated to 50C and stirred for 15 h. TLC showed that the reactants were completely consumed; then solid werefiltered, and the filtrate was concentrated under reduced pressure, residues were dissolved in toluol (100 mL), then thesolvent toluol was spin-dried to obtain methyl 6-methylpiperidyl-3-carboxylatewhich was yellow oily matter (18.00 g, yieldwas 96.15%). The value of C8H15NO2[M+H]+157 was calculated using MS ESI, was 157.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5470-70-2, Methyl 6-methylnicotinate.

Reference:
Patent; Wuxi Fortune Pharmaceutical Co., Ltd; WU, Hao; MAO, Weiwei; FAN, Lili; DING, Charles Z.; CHEN, Shuhui; WANG, Fei; HU, Guoping; LI, Jian; (85 pag.)EP3248980; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

74115-13-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 74115-13-2, name is 5-Bromo-3-pyridinol, molecular formula is C5H4BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

5-bromopyridin-3-ol (100 mg, 0.575 mmol), silver carbonate (475 mg, 1.724 mmol), and benzyl bromide (68.4 muL, 0.575 mmol) were dissolved in CHCl3 (2874 muL) and stirred for 18 hours. The reaction mixture was filtered to remove the silver salts and concentrated in vacuo. The crude material was purified by column chromatography (ISCO, 12 g silica gel column, 19 minute gradient from 0 to 100% EtOAc in hexanes) to give Intermediate 14A (41.2 mg, 0.156 mmol, 27.1%) as a yellow oil: 1H NMR (0455) (400MHz, CHLOROFORM-d) delta 8.30 (dd, J=4.4, 2.4 Hz, 2H), 7.45-7.33 (m, 6H), 5.10 (s, 2H); LC^MS: Method H, RT = 0.99 min, MS (ESI) m/z: 264/266 (M+H)+.

The chemical industry reduces the impact on the environment during synthesis 74115-13-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; RICHTER, Jeremy M.; ZHANG, Xiaojun; PRIESTLEY, Eldon Scott; (111 pag.)WO2018/13772; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

5470-18-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5470-18-8, name is 2-Chloro-3-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows.

1.a 3-Nitro-2-phenoxypyridine 3.6 g (150 mmol) of sodium hydride were added, a little at a time, to a mixture of 12 g (128 mmol) of phenol and 100 ml of dimethylformamide. After the evolution of gas had ceased, the resulting mixture was treated with 18 g (114 mmol) of 2-chloro-3-nitropyridine. After the reaction mixture had been stirred at room temperature (approximately 25 C.) for 3 hours, it was treated with water. Following extraction with tert-butyl methyl ether, washing and drying the organic phase and removal of the solvent under reduced pressure, the product crystallized out. It was purified further by stirring with tert-butyl methyl ether/n-pentane. This gave 6.6 g (27%) of the title compound. A further 3.0 g (12%) of the title compound were obtained from the mother liquor. 1 H NMR (CDCl3; delta in ppm): 7.1 (m,3H, phenyl); 7.2 (t,1H); 7.4 (t, br, 2H); 8.3 (m,2H, pyridyl).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5470-18-8, 2-Chloro-3-nitropyridine.

Reference:
Patent; BASF Aktiengesellschaft; US5977146; (1999); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1003-68-5, name is 5-Methylpyridin-2(1H)-one. This compound has unique chemical properties. The synthetic route is as follows. 1003-68-5

1 (10.9 g, 0.1 mol) and 2 (31.6 g, 0.12 mol) were dissolved in dry DMF (200 mL) under N2 atmosphere, then anhydrous K2CO3 (27.6 g, 0.2 mol) and CuI (3.8 g, 0.02 mol) were added. The reaction mixture was refluxed for 10 h. After cooling, the mixture was quenched with saturated NaHCO3 (aq, 150 mL), and extracted with EtOAc (3¡Á50 mL), the organic layers were collected, dried over anhydrous Na2SO4, filtered and concentrated, crystallized from EtOAc /PE. The desired product 3 was obtained as a yellowish solid (21.5 g, 74%), mp: 123-124. 1HNMR (400MHz, CDCl3): delta 7.05-7.46 (m, 11H), 6.62 (d, J=9.2 Hz, 1H), 5.11 (s, 2H), 2.10 (s, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1003-68-5, 5-Methylpyridin-2(1H)-one.

Reference:
Article; Ma, Zhen; Pan, Youlu; Huang, Wenhai; Yang, Yewei; Wang, Zunyuan; Li, Qin; Zhao, Yin; Zhang, Xinyue; Shen, Zhengrong; Bioorganic and Medicinal Chemistry Letters; vol. 24; 1; (2014); p. 220 – 223;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

1604-14-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1604-14-4, name is 2,6-Dichloro-isonicotinic acid ethyl ester. A new synthetic method of this compound is introduced below.

A solution of phenylboronic acid (915 mg, 7.50 mmol) in methanol (15 mL) was added to a stirred solution of ethyl-2,6- dichloro-isonicotinate (750 mg, 3.41 mmol) and tetrakis- (TRIPHENYLPHOSPHINE)-PALLADIUM (0) (197 mg, 5 mol%) in toluene (60 mL). 2N sodium carbonate (3.41 mL, 6.82 mmol) was added and the reaction was heated to 90C (oil bath temp. ) for 2-3 hrs until complete (TLC control). The reaction mixture was cooled to room temperature and partitioned between water and diethyl ether. The phases were separated, the aqueous phase being further extracted with diethyl ether (3 x 30 mL). The combined extract was washed with water and brine. The ethereal solution was dried over anhydrous MGS04, filtered and concentrated in vacuo to yield the title compound as a white solid (941 mg, 91 %) ; Rf: 0.5 (30% ethyl acetate in heptane); 1H NMR (CDC13, 300 MHz) 6 8.18 (2H, s, ArH), 8.12 (4H, m, ArH), 7.42 (6H, m, ArH), 4.38 (2H, q, J = 7 Hz, CH20), 1.39 (2H, t, J = 7HZ, CH3).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1604-14-4, 2,6-Dichloro-isonicotinic acid ethyl ester, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE INSTITUTE OF PHARMACEUTICAL DISCOVERY, LLC; WO2004/99192; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 72830-09-2, name is 2-Chloromethyl-3,4-dimethoxypyridinium chloride, molecular formula is C8H11Cl2NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 72830-09-2

To the reaction flask was added 10 g of 2-chloromethyl-3,4-dimethoxypyridine hydrochloride(Compound 1), 10 g of 5-difluoromethoxy-2-mercapto-1H-benzimidazole(Compound 2), 100 ml of methylene chloride was added, and 130 g of a 10% sodium hydroxide solution was added dropwise, and the mixture was stirred at 20 to 30 C for 2 hours, Static separation, dichloromethane layer washed twice, each time with water 30ml,And then distilled under reduced pressure to give 16.6 g of a yellow oil (Intermediate 3);

The chemical industry reduces the impact on the environment during synthesis 72830-09-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Qilu Tianhe Huishi Pharmaceutical Co., Ltd.; Qin Chunxia; Li Baoyong; Wu Ke; Zhang Zhaozhen; Dong Tinghua; (6 pag.)CN105111187; (2017); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

7379-35-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7379-35-3, name is 4-Chloropyridine hydrochloride, molecular formula is C5H5Cl2N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 3-aminothiophenol (3.8 mL, 34 mmoles) in anh DMF (90mL) was added 4-chloropyridine hydrochloride (5.4 g, 35.6 mmoles) followed by K2CO3 (16.7 g, 121 mmoles). The reaction mixture was stirred at room temp. for 1.5 h, then diluted with EtOAc (100 mL) and water (100mL). The aqueous layer was back-extracted with EtOAc (2 x 100 mL). The combined organic layers were washed with a saturated NaCl solution (100 mL), dried (MgSO4), and concentrated under reduced pressure. The residue was filtered through a pad of silica (gradient from 50percent EtOAc/50percent hexane to 70percent EtOAc/30percent hexane) and the resulting material was triturated with a Et2O/hexane solution to afford the desired product (4.6 g, 66percent): TLC (100 percent ethyl acetate) Rf 0.29; 1H-NMR (DMSO-d6) delta 5.41 (s, 2H), 6.64-6.74 (m, 3H), 7.01 (d, J=4.8, 2H), 7.14 (t, J=7.8 Hz, 1H), 8.32 (d, J=4.8, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7379-35-3, 4-Chloropyridine hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Bayer Pharmaceuticals Corp.; EP1047418; (2005); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

115473-15-9 , The common heterocyclic compound, 115473-15-9, name is 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridin-2(4H)-one hydrochloride, molecular formula is C7H10ClNOS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 5: Methyl(S)-2(2-chlorophenyl)-2-(2,4,5,6,7,7a-hexahydrothieno [3,2-c]-5- pyridin-2-one)acetate[0064] In a dry, 250-ml reaction flask, 5.94 gm (31.1 mmoles) of 5,6,7, 7a-tetrahydro-4H- thieno[3,2-c]pyridin-2-one hydrochloride, 39 ml of dichloromethane and 29.8 g of a 30% aqueous solution of potassium carbonate were mixed. After stirring for 10 minutes, 10 gm of (25.9 mmoles of Methyl (R)-2- (4-nitrophenylsulfonyloxy)-2(2-chlorophenyl)acetate as a solution in 13 ml of dichloromethane was added. The two-phase medium thus obtained was heated under reflux for 6 hrs. Then cooled to about 30C. Filtered the R.M. Filtrate was having two layers. MDC layer was washed with brine solution. Dried over anhydrous sodium sulfate. After concentration Methyl(S)-2(2-chlorophenyl)-2- (2,4,5,6,7,7a-hexhydrothieno[3,2-c]-5-pyridin-2-one)acetate [(S)-thiolactone of Formula II ] was obtained.

According to the analysis of related databases, 115473-15-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; IPCA LABORATORIES LIMITED; KUMAR, Ashok; NELLITHANATH, Thankachen, Byju; WO2012/25942; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1122-62-9, 1-(Pyridin-2-yl)ethanone, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1122-62-9, blongs to pyridine-derivatives compound. 1122-62-9

General procedure: To a 25 mL Schlenk tube containing a solution of 1 in 2 mL of THF was added an aldehyde (1.0 mmol) and (EtO)3 SiH (0.20 g, 1.2 mmol). The reaction mixture was stirred at 50-55 C until there was no aldehyde left (monitored by TLC and GC-MS). The reaction was then quenched byMeOH (2mL) and a 10% aqueous solution of NaOH (5 mL) with vigorous stirring at 60 C for about 24 h.The organic product was extracted with diethyl ether (10 mL ¡Á 3), dried over anhydrous MgSO4, and concentrated under vacuum. The alcohol product was further purified using flash column chromatography (elute with 5-10% ethyl acetate in petroleum ether). The 1H NMR and 13C NMR spectra of the alcohol products are providedin Supporting information.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1122-62-9, its application will become more common.

Reference:
Article; Xue, Benjing; Sun, Hongjian; Niu, Qingfen; Li, Xiaoyan; Fuhr, Olaf; Fenske, Dieter; Catalysis Communications; vol. 94; (2017); p. 23 – 28;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

271-63-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 271-63-6, name is 1H-Pyrrolo[2,3-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows.

10.0 g (84.65 mmol) of 7-azaindole was suspended in 300 ml of CCl 4 and 4.35 mL (84.65 mmol) of Br 2 slowly at room temperatureAnd stirred for 12 hours under a stream of nitrogen. After completion of the reaction, the resulting solid was filtered,The reaction mixture was dissolved in loromethane and extracted with Na2S2O3. The organic solvent was removed and dried to obtain 12.0 g (yield: 72%) of the intermediate product (A)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 271-63-6, 1H-Pyrrolo[2,3-b]pyridine.

Reference:
Patent; Cheil Industries Co., Ltd.; Hong, Jin Suk; Yu, Dong Gyu; Yu, Uhn Sun; Lee, Han Ir; Kang, Dong Min; Lee, Sang Sin; Jang, Yuna; Jung, Su Young; Han, Su Jin; (31 pag.)KR2015/15252; (2015); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem