Day: December 24, 2020

Reference of 18653-75-3, Adding some certain compound to certain chemical reactions, such as: 18653-75-3, name is 2-(1H-Imidazol-2-yl)pyridine,molecular formula is C8H7N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18653-75-3.

Chromium(III) chloride hexahydrate (0.266 g, 1 mmol) and pyim(0.145 g, 1 mmol) were disolved in 50 cm3 of water and refluxed for onehour at 80 C under continuous stirring. An aqueous solution of lithiumoxalate (2 mmol, 20 cm3) [generated in situ by reaction of stoichiometricamounts of oxalic acid and lithium hydroxide] was added andthe reflux was continued to 1.5 h. During this time, the initial greensolution turned deep violet. The resulting solution was filtered to discardany small solid particle and allowed to evaporate at room temperature.Reddish brown chunky crystals separated in several crops asfar as the volume was reduced during two weeks. They were collected by filtration and dried on filter paper. The recrystallization in methanol afforded X-ray quality crystals of 1 as reddish brown prisms. The yield is ca. 80%. Anal. Calc. for C13H11CrLiN3O9 (1): C, 37.89; H, 2.67; N,10.19. Found: C, 37.68; H, 2.58; N, 10.08%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 18653-75-3, 2-(1H-Imidazol-2-yl)pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Fortea-Perez, Francisco Ramon; Pasan, Jorge; Pascual-Alvarez, Alejandro; Ruiz-Perez, Catalina; Julve, Miguel; Lloret, Francesc; Inorganica Chimica Acta; vol. 486; (2019); p. 150 – 157;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 271-73-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 271-73-8, name is 1H-Pyrazolo[3,4-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows.

A. 3-lodo-I H-pyrazolo[3,4-b]pyridineTo a solution of iH-pyrazolo[3,4-b]pyridine (2.00 g, i6.8 mmol) in DMF (35 mL) were added iodine (6.39 g, 25.2 mmol) and potassium hydroxide (2.35 g, 42.0 mmol). The reaction mixture was stirred at RT for i6 h. The mixture was diluted with iO% sodium thiosulfate and water and the resulting suspension was filtered to give the title compound as a yellow powder. TLC, R (EtOAc) = 0.8; MS (UPLCMS): 246.0 [M+H]+, 243.9 [M-H]-; tR (HPLC conditions f): i .3i mm.

According to the analysis of related databases, 271-73-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; HOMMEL, Ulrich; LORTHIOIS, Edwige Liliane Jeanne; MAIBAUM, Juergen Klaus; OSTERMANN, Nils; RANDL, Stefan Andreas; VULPETTI, Anna; WO2014/2057; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1597-32-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1597-32-6, name is 2-Amino-6-fluoropyridine, molecular formula is C5H5FN2, molecular weight is 112.11, as common compound, the synthetic route is as follows.

General procedure: To the solution of Acid SM-IX (750 mg, 2.i8 mmol, iOO mol-%) in dry DCM (iO ml) under nitrogen atmosphere was added 3-amino-5- methylisoxazole (427 mg, 4.36 mmol, 200 mol-%) and pyridine (526 p1, 6.53mmol, 300 mol-%). T3P (50 w-% in EtOAc) (2.6 ml, 4.36 mmol, 200 mol-%) was added dropwise and the reaction mixture stirred at rt for four hours. DCM (i 0 ml) and i 0 % NaH 003 (30 ml) were added. The water phase was extracted twice with DCM (2 x iO ml). The organic phases were combined and washed with 0.i N HCI solution (3 x 30 ml), water (3 x 30 ml) and finally withbrine (3 x 30 ml) and dried with sodium sulfate. The crude yield of compound i was 95 % (875 mg).1H NMR (200 MHz, DMSO-d6): 0.97 (5, 3 H), i.24 -2.46 (m, i6 H),2.37 (5, 3H), 2.58 – 3.Oi (m, 2 H), 6.64 (5, i H), 6.88-7.06 (m, i H), 7.07 – 7.25 (m, 2 H), iO.88 (5, i H).

The chemical industry reduces the impact on the environment during synthesis 1597-32-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; FORENDO PHARMA LTD; HIRVELAe, Leena; HAKOLA, Marjo; LINNANEN, Tero; KOSKIMIES, Pasi; STJERNSCHANTZ, Camilla; (182 pag.)WO2018/224736; (2018); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 133081-24-0, 6-Hydrazinylnicotinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C6H7N3O2, blongs to pyridine-derivatives compound. HPLC of Formula: C6H7N3O2

General procedure: A 0.5M solution of 2-chloropyridine-5-carboxylic acid (15 mmol) was treated with hydrazine hydrate (150 mmol, added at once) and heated at reflux for 72 h. The suspension was concentrated to dryness. The residue was dissolved in water and acidified (pH = 3) with acetic acid. The precipitate of 2-hydrazinopyridine-5-carboxylic acid that formed in 15 min was filtered off, washed with water and air-dried. It was dissolved in the respective aliphatic carboxylic acid and the solution (0.5M) was heated at reflux for 48 h. Upon cooling to room temperature, the volatiles were removed in vacuo and the residue was triturated with 1M aqueous sodium bicarbonate. The precipitate thus formed was filtered off, washed with water and air dried. The resulting 1,2,4-triazolo[4,3-a]pyridine 12 was dissolved in methanol (0.25M and was hydrogenated over Pd(OH)2 catalyst (0.1 equiv.) at 100 atm and 100 C over 24 hours. The mixture was filtered while still hot and concentrated in vacuo. The residue was crystallized from isopropyl alcohol to provide analytically pure carboxylic acids 11a-d.

The synthetic route of 133081-24-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Mishchuk, Alexander; Shtil, Natalia; Poberezhnyk, Mykola; Nazarenko, Konstiantyn; Savchenko, Timur; Tolmachev, Andrey; Krasavin, Mikhail; Tetrahedron Letters; vol. 57; 9; (2016); p. 1056 – 1059;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1210838-82-6, name is 5-Bromo-3-ethynylpyridin-2-ylamine. A new synthetic method of this compound is introduced below., Product Details of 1210838-82-6

Step 3: 5-Bromo-3-(3-(((tert-butyldimethylsilyl)oxy)methyl)isoxazol-5-yl)pyridin-2-amine To a suspension of 5-bromo-3-ethynylpyridin-2-amine (Intermediate C15) (500 mg, 2.54 mmol) and sodium ascorbate (0.254 ml, 0.254 mmol) in t-BuOH (10 ml) and water (10ml) under N2 was added copper(ll) sulfate pentahydrate (13mg, 0.051 mmol, 2mol%) and NaHCOs (853mg, 10.15mmol) followed by 2-((tert-butyldimethylsilyl)oxy)-N- hydroxyacetimidoyl chloride (step 3) (1.7g, 7.61 mmol, 3eq) slowly over 15mins. The mixture was stirred at RT overnight. The resulting mixture was extracted into DCM, washed with water, brine, the organic layer separated, dried over MgS04, filtered and the solvent removed under reduced pressure. The crude product was purified by flash column chromatography elution with iso-hexane:ethyl acetate (0-30%) on a 24g silica cartridge. The required fractions were combined and the solvent removed under reduced pressure to afford the title compound; LCMS: Rt = 1.62mins MS m/z 384.4 [M+H]+; Method 2minl_owpHv03.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1210838-82-6, 5-Bromo-3-ethynylpyridin-2-ylamine.

Reference:
Patent; NOVARTIS AG; BELLENIE, Benjamin Richard; BLOOMFIELD, Graham Charles; BRUCE, Ian; CULSHAW, Andrew James; HALL, Edward Charles; HOLLINGWORTH, Gregory; NEEF, James; SPENDIFF, Matthew; WATSON, Simon James; WO2015/162456; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 175461-33-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 175461-33-3 as follows.

Sulfuric acid (60 mL) was cooled to 0 0C and (2,6-dichloro-pyridin-4-yl)- methylamine (11.9 g, 62.51 mmol) was added. Nitric acid (2.59 mL, 62.51 mmol) was added dropwise. The resulting yellow solution was stirred at 00C for 1 hour. The reaction mixture was poured into ice water (600 ml_). Ethyl acetate was added and the phases separated. The aqueous phase was extracted with ethyl acetate. The combined organic phases were washed with aqueous sodium carbonate, dried over magnesium sulphate, filtrated and evaporated to give a yellow solid. The solid was redissolved in sulfuric acid poured into ice water (500 ml_). The resulting solid was filtered off and washed with water to give (2,6-dichloro-3-nitro-pyridin-4-yl)-methyl- amine (10.5 g, 76%) as a yellow crystalline compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,175461-33-3, its application will become more common.

Reference:
Patent; NeuroSearch A/S; WO2008/92942; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 89284-61-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 89284-61-7, name is 4-Chloronicotinonitrile. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of ethanolamine (0.60 mL, 10.0 mmol), 4-chloronicotinonitrile (1.38 g, 10.0 mmol) and diisopropylethylamine (1.74 mL, 10.0 mmol) in isopropanol was heated at reflux for 2.5 hours. It was cooled to room temperature and loaded on to a 5Og SCX-2 cartridge preconditioned with methanol. The cartridge was eluted with methanol and then with a 2M solution of ammonia in methanol. Collecting appropriate fractions followed by evaporation of solvents gave the title compound as a beige solid (1.20 g, 74%). 1H NMR (d6-DMSO, 400MHz) 8.40 (s, IH), 8.21 (d, J = 6.3 Hz, IH), 6.94 (bs, IH), 6.77(d, J = 6.3 Hz, IH), 4.84 (bs, IH), 3.55 (t, J = 6.0 Hz, 2H), 3.31 (dt, J = 6.0 Hz, 6.0 Hz, 2H). [00301] Step 2: 4-(2-Triisopropylsilanyloxy-ethylamino)-nicotinonitrile

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 89284-61-7, 4-Chloronicotinonitrile.

Reference:
Patent; GENENTECH, INC.; WO2008/67481; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 5470-66-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5470-66-6, name is 4-Nitro-2-picoline N-oxide. This compound has unique chemical properties. The synthetic route is as follows.

4-NITROPICOLINE-N-OXIDE (10.0 g, 64.9 mmol) and DIMETHYLSULFATE (6.39 mL, 64.5 mmol) were heated at 70 C for 6 hours under a nitrogen gas (N2) atmosphere. The dark brown mixture, which solidified upon cooling to room temperature was dissolved in 20 mL of water, cooled to -10 C WHILE vigorously stirring, and treated dropwise with a solution of KCN (5.04 g, 77.4 mmol) in 20 mL of water. The mixture was warmed to room temperature overnight. The resulting black heterogeneous mixture was dissolved in 50 ML of ethyl acetate and 50 mL of water. The phases were separated and the aqueous layer was extracted with two 50 mL portions of ethyl acetate. The combined organic layers were dried over magnesium sulfate, filtered, and concentrated in VACUO. Flash chromatography (20% to 50% ethyl acetate in hexanes, gradient) afforded the product as a brown solid (2.80 g, 27% yield). 2-Cyano-6-methyl-4-nitropyridine (1.9 g, 11.6 mmol) in a mixture of 50 mL of ethanol and 15 ML of saturated aqueous ammonium chloride (NH4C1) solution was heated with indium powder (7.00 g, 60.9 mmol) to 60 C for 3 days. 20 mL of water was then added, and the slurry was filtered through CELTES filter aid and the pad was washed with methanol. The filtrate was concentrated IN VACUO to remove volatile organics and extracted with three 20 ML portions of dichloromethane. The combined extracts were dried over magnesium sulfate, filtered, and concentrated in vacuo. Chromatography on SI02 (30% ethyl acetate in hexanes to 100% ethyl acetate, gradient) gave the product as a tan solid (580 mg, 27% yield). 4-Amino-6-methylpyridine-2-carbonitrile was converted to the title product in 57% yield according to the procedure described for the preparation of 4-amino-3-bromo-2,6- dimethylpyridine.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5470-66-6, 4-Nitro-2-picoline N-oxide.

Reference:
Patent; BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.; WO2005/30213; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 885276-93-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 885276-93-7, name is Ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylate. A new synthetic method of this compound is introduced below.

Synthesis of 5-bromo-N, N-bis(4-methoxybenzyl)pyrazolo[ 1 , 5-a]pyridine-3-carboxamide-26)1-25 1-26[000270] To a suspensions of ethyl 5-bromopyrazolo[1 ,5-a]pyridine-3-carboxylate (0.27 g, 1 .0 mmol) in EtOH (5 ml_) was added 6 N KOH (0.3 uL, 2.0 mmol). The reaction was heated to reflux for 3 hours then cooled to room temperature and neutralized to pH 6 with 1 M HCI. The resulting solid was filtered and dried under vacuum to yield 5-bromopyrazolo[1 ,5-a]pyridine-3-carboxylic acid (I-25) as a white solid. 1 H NMR (400MHz, DMSO-c/6) delta 8.83 (d, J = 7.6 Hz, 1 H), 8.42 (s, 1 H), 8.21 (d, J = 2.4 Hz, 1 H), 7.30 (dd, J = 2.0, 7.6 Hz, 1 H). MS m/z 240.9, 242.9 (M+1 )+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,885276-93-7, its application will become more common.

Reference:
Patent; IRM LLC; MOLTENI, Valentina; FAN, Yi; LOREN, Jon; SMITH, Jeffrey M.; FLATT, Brenton T.; WO2012/116217; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1173081-96-3, name is 3-(Aminomethyl)-4,6-dimethylpyridin-2(1H)-one hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 1173081-96-3

To a stirred solution of 5-bromo-3-(sec-butyl(methyl)amino )-2-methylbenzoic acid(500 mg, 1.666 mmol), EDC (479 mg, 2.498 mmol), and HOBT (383 mg, 2.498 mmol) indimethyl sulfoxide (DMSO) (40 mL) was added N-methylmorpholine (0.732 mL, 6.66mmol), followed by 3-(aminomethyl)-4,6-dimethylpyridin-2(1H)-one hydrochloride (377mg, 1.999 mmol). The reaction mixture was stirred at 25 oc for 16 h. The reaction mixture was poured onto ice water (50 mL), stirred for 10 min, allowed to stand for 10 min, andthen filtered. The collected solid was rinsed with water (50 mL), followed by 10%MeOH/ice water (50 mL) and diethyl ether (25 mL). The contents were filtered and dried to afford 400 mg of crude product. The product was purified by silica gel chromatography(eluent: 100% EtOAc) to afford the title compound (200 mg, 27% yield) as an off-whitesolid. 1H NMR (400 MHz, DMSO-d6) 8 ppm 0.83 (t, 3H, J = 7.5 Hz), 0.96 (d, 3H, J = 6.4Hz), 1.41-1.49 (m, 1H), 1.51-1.57 (m, 1H), 2.11 (s, 6H), 2.18 (s, 3H), 2.53 (s, 3H), 2.90-2.96 (m, 1H), 4.23 (d, 2H, J = 4.9 Hz), 5.85 (s, 1H), 6.99 (s, 1H), 7.14 (s, 1H), 8.17 (t, 1H,J = 4.9 Hz), 11.5 (s, 1H). LCMS(ES) [M+Ht 434.5.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1173081-96-3, 3-(Aminomethyl)-4,6-dimethylpyridin-2(1H)-one hydrochloride.

Reference:
Patent; GLAXOSMITHKLINE LLC; BURGESS, Joelle, Lorraine; DUQUENNE, Celine; KNIGHT, Steven, David; MILLER, William, Henry; NEWLANDER, Kenneth, Allen; VERMA, Sharad, Kumar; WO2013/173441; (2013); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem