Day: January 8, 2021

Adding a certain compound to certain chemical reactions, such as: 861673-68-9, 2-(2-(tert-Butyl)phenoxy)pyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-(2-(tert-Butyl)phenoxy)pyridin-3-amine, blongs to pyridine-derivatives compound. Recommanded Product: 2-(2-(tert-Butyl)phenoxy)pyridin-3-amine

104a 1-(2-(2-tert-butylphenoxy)pyridin-3-yl)-3-(2, 4-dichlorophenyl) thiourea [00324] A solution of lb (40 mg, 0.17 mmol) and 2,5- dichlorophenylisothiocyanate (37 mg, 0.18 mmol) in dioxane (2 mL) was heated at 60C for 6 h. More 2,5-dichlorophenylisothiocyanate (37 mg, 0.18 mmol) was added and the mixture was heated at 60C for 8 days. The mixture was concentrated and the residue was purified by column chromatography on silica gel using a continuous gradient from 0% to 40% ethyl acetate in hexanes as eluant. Half of the material was carried to the next step without further purification, the other half was purified by preparative HPLC (continuous gradient from 40% B to 100%, B; A = 90: 10: 0.1 H20 : MeOH: TFA; B = 90 : 10: 0.1 MeOH: H2O : TFA) to afford 104a (8 mg, 43%). 1H NMR (400 MHz, CD30D) 8 ppm 1. 38 (m, 9 H), 6.93 (dd, J=7. 83,1. 52 Hz, 1 H), 7.15 (m, 3 H), 7. 31 (dd, J=8. 59, 2.27 Hz, 1 H), 7.44 (dd, J=7. 83,1. 77 Hz, 1 H), 7.52 (d, J=2. 53 Hz, 1 H), 7.68 (d, J=8. 59 Hz, 1 H), 7.90 (dd, J=5. 05,1. 77 Hz, 1 H), 8.35 (dd, J=7. 71,1. 89 Hz, 1 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,861673-68-9, 2-(2-(tert-Butyl)phenoxy)pyridin-3-amine, and friends who are interested can also refer to it.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2005/70920; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4487-59-6, name is 2-Bromo-5-nitropyridine. A new synthetic method of this compound is introduced below., HPLC of Formula: C5H3BrN2O2

Example 84Synthesis of 3-[6-{4-[5-(nitro)pyridin-2-yl]piperazin-l-yl}-5-phenyl-2- (trifluoromethyl)pyrimidin-4-yl]benzenesulfonamide.Step 1;Preparation of l-(5-nitropyridin-2-yl) piperazine. 2-Bromo-5-nitropyridine (0.3g, 1.48mmol) was treated with piperazine (0.64g, 7.89mmol) in tetrahydrofuran (4mL) and the reaction mixture was stirred for 30 minutes. Subsequently the reaction mixture was poured onto ice- cold water (25mL) and extracted with ethyl acetate (25mL). The organic layer was washed with brine and evaporated to furnish the product.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4487-59-6, 2-Bromo-5-nitropyridine.

Reference:
Patent; ORCHID RESEARCH LABORATORIES LIMITED; WO2007/83182; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1721-26-2, name is Ethyl 2-methylnicotinate. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C9H11NO2

EXAMPLE 181 3-{[5-(2-Adamantan-1-yl-ethyl)-2-(2-methyl-pyridine-3-yl)-1H-imidazole-4-carbonyl]-amino}-benzoic Acid 5-(2-Adamantan-1-yl-ethyl)-2-(2-methyl-pyridine-3-yl)-1H-imidazole-4-carboxylic acid was prepared according to the procedure of Example 70, steps a and b, with the modification that 2-methyl-pyridine-3-carboxaldehyde (prepared from ethyl 2-methylnicotinate in two steps) was used in step a instead of 2-dimethylamino-benzaldehyde. It was reacted with 3-amino-benzoic acid benzyl ester according to the procedure of Example 20, step d to afford 3-{[5-(2-adamantan-1-yl-ethyl)-2-(2-methyl-pyridine-3-yl)-1H-imidazole-4-carbonyl]-amino}-benzoic acid benzyl ester. The benzyl group was removed following the procedure of Example 1, step e, to afford the title compound as a white solid. 1H NMR (300 MHz, d6-DMSO) 12.70 (1H, br s), 9.77 (1H, s), 8.49 (2H, m), 7.97 (2H, m), 7.62 (1H, d), 7.41 (1H, t), 7.35 (1H, dd), 2.87 (2H, m), 2.76 (3H, s), 1.95 (3H, br s), 1.69 (6H, m), 1.54 (6H, m), 1.44 (2H, m).

With the rapid development of chemical substances, we look forward to future research findings about 1721-26-2.

Reference:
Patent; James Black Foundation Limited; US6479531; (2002); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 73027-79-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 73027-79-9, name is 4,6-Dichloronicotinic acid. This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of 4,6-dichloronicotinic acid (1 .0 g, 5.21 mmol) in N,N-dimethylformamide (15 mL) was added N,O-dimethylhydroxylamine (1 .02 g, 10.42 mmol), hydroxybenzotriazole (1 .41 g, 10.4mmol), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (2.0 g, 10.4 mmol) and N-ethyl-N-(propan-2- yl)propan-2-amine (2.02 g, 15.6 mmol, 2.73 mL). The mixture was stirred at 20 00 for 48 h. The reaction mixture was quenched by addition of water (20 mL) then the mixture was extracted with ethyl acetate (50 mL x 3). The combined organic phases were washed with saturated aqueous sodium chloride solution (20 mL), dried over anhydrous sodium sulfate, filtered and concentrated to give a crude residue that waspurified by chromatography (silica, petroleum ether : ethyl acetate 50:1 to 5:1 to give 4,6-dichloro-N- methoxy-N-methylnicotinamide (660 mg, 2.81 mmol, 54 %) as a yellow oil.1H NMR (400 MHz, ODd3) O 8.37 (s, 1 H), 7.45 (s, 1 H), 3.51 (br s, 3H), 3.40 (br s, 3H).

According to the analysis of related databases, 73027-79-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; YUMANITY THERAPEUTICS; LUCAS, Matthew; LE BOURDONNEC, Bertrand; WRONA, Iwona; PANDYA, Bhaumik; TIVITMAHAISOON, Parcharee; OZBOYA, Kerem; VINCENT, Benjamin; TARDIFF, Daniel; PIOTROWSKI, Jeff; SOLIS, Eric; SCANNEVIN, Robert; CHUNG, Chee-Yeun; ARON, Rebecca; RHODES, Kenneth; (489 pag.)WO2018/81167; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 58530-50-0, 2-(Pyridin-2-yloxy)acetic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 58530-50-0, blongs to pyridine-derivatives compound. Quality Control of 2-(Pyridin-2-yloxy)acetic acid

General procedure: To the mixture of compounds (IVa-c)(2 mmol) in dry acetonitrile (15 mL), triethylamine(3 mmol) followed by substituted piperazines(2 mmol) was added. The mixture was stirred for30 min and TBTU (2mmol) was then added and stirring was continued at room temperature under an inert atmosphere for 10-24 h; the completion of thereaction was monitored by TLC using chloroform-methanol (9 : 1) as eluent. The solvent was evaporatedat reduced pressure, quenched by the addition of coldwater (20 mL), and the obtained solids (Va), (Vb), (Vc),(Vd), (Ve), (Vf), (Vi), and (Vk) were filtered, dried, andrecrystallized from ethanol. In contrast, compounds(Vg), (Vh), (Vj), and (Vl) were obtained by extractingwith ethyl acetate. The extract was washed successivelywith a solution of 10% HCl (20 mL), 10% NaHCO3(20 mL), and water (20 mL). The organic layer wasdried over anhydrous sodium sulfate and evaporated,the crude product was purified by column chromatography (eluent: hexane-dichloromethane-acetone,5 : 3 : 2) to achieve pure piperazine derivatives. Thephysical and analytical data of the synthesized titlecompounds (Va-l) are given below.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,58530-50-0, its application will become more common.

Reference:
Article; Al-Ghorbani; Rekha; Lakshmi Ranganatha; Prashanth; Veerabasappagowda; Khanum; Russian Journal of Bioorganic Chemistry; vol. 41; 5; (2015); p. 554 – 561; Bioorg. Khim.; vol. 41; 5; (2015); p. 554 – 561,8;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 944401-56-3, Adding some certain compound to certain chemical reactions, such as: 944401-56-3, name is 5-Bromo-4-(trifluoromethyl)pyridin-2-amine,molecular formula is C6H4BrF3N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 944401-56-3.

Method 4: N’-(5-bromo-4-(trifluoromethyl)pyridin-2-yl)-N,N-dimethylformimidamide (I9) (0161) (0162) 2-amino-6-(trifluoromethyl)pyridine (25.0 g, 156 mmol, 1.0 eq.) in dimethyl acetal (25.1 mL, 188 mmol, 1.2 eq.) was added and the mixture was heated at 70 C for 6 hours. The solvent was oratory evaporated under reduced pressure and the residue was recrystallized from hexane to yield the desired 29 product I9 as an off-white solid (65% yield). 1H NMR (400 MHz, CDCl3): delta 8.46 (s, 1 H), 8.38 (s, 1 H), 7.18 (s, 1 H), 3.11 (s, 3 H), 3.08 (s, 3 H); 19F{1H} NMR (376 MHz, CDCl3): delta – 65.0 (s, 3 F).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 944401-56-3, 5-Bromo-4-(trifluoromethyl)pyridin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Universitaet Basel; Bohnacker, Thomas; Rageot, Denise; Sele, Alexander Markus; Beaufils, Florent; Wymann, Matthias; (51 pag.)EP3231799; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 918511-92-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 918511-92-9, name is 5-(Pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine, molecular formula is C12H9N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To 3-nitrobenzaldehyde (534, 1.08 g, 7.17 mmol) in methanol (34 niL) was added 5- pyridin-3-yl-lH-pyrrolo[2,3-b]pyridme (89, 1.08 g, 5.52 mmol, prepared as described in Example 17) and potassium hydroxide (1.55 g, 27.6 mmol). The reaction was stirred at room temperature for four hours. The reaction was poured into water and extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate and concentrated. The mixture was purified by silica gel column chromatography eluting with 4% methanol in dichloromethane to provide two different compounds, a white solid (P-1399, R = H, 1.20 g, 63%) MS(ESI) [MMf]+ = 347.2, and a light yellow solid (535, R = Me, 0.434 g, 22%).

According to the analysis of related databases, 918511-92-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PLEXXIKON, INC.; WO2007/2325; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1101120-05-1, 3-Formylpyrazolo[1,5-a]pyridine-5-carbonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 1101120-05-1, blongs to pyridine-derivatives compound. SDS of cas: 1101120-05-1

General procedure: These were made using NaHCO3 or 2,6-lutidine as detailed below, unless otherwise stated. Methylhydrazine sulfate (1.2 equiv) and NaHCO3 (5 equiv) were added to a solution of 3-formylpyrazolo[1,5-a]pyridine-5-carbonitrile (2) (1 equiv) in MeOH (5 mL). After all of the aldehyde was consumed, sulfonyl chloride or acyl chloride (1.3 equiv) was added and the reaction mixture stirred for a further 30 min. The solvent was removed in vacuo and the residue taken up in CH2Cl2 and water. The layers were separated and the aqueous phase extracted with CH2Cl2, then the combined organic layers were dried (Na2SO4) and the solvent removed in vacuo. Chromatography or trituration then afforded the hydrazides. Alternatively, methylhydrazine sulfate (1.2 equiv) and 2,6-lutidine (5 equiv) were added to a solution of 2 (1 equiv) in MeOH (5 mL). After all of the aldehyde was consumed, sulfonyl chloride or acyl chloride (1.3 equiv) was added and the reaction mixture stirred for a further 30 min. The hydrazide was then filtered off, washed with MeOH and dried.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1101120-05-1, 3-Formylpyrazolo[1,5-a]pyridine-5-carbonitrile, and friends who are interested can also refer to it.

Reference:
Article; Kendall, Jackie D.; Giddens, Anna C.; Tsang, Kit Yee; Frederick, Raphael; Marshall, Elaine S.; Singh, Ripudaman; Lill, Claire L.; Lee, Woo-Jeong; Kolekar, Sharada; Chao, Mindy; Malik, Alisha; Yu, Shuqiao; Chaussade, Claire; Buchanan, Christina; Rewcastle, Gordon W.; Baguley, Bruce C.; Flanagan, Jack U.; Jamieson, Stephen M.F.; Denny, William A.; Shepherd, Peter R.; Bioorganic and Medicinal Chemistry; vol. 20; 1; (2012); p. 58 – 68;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 109-09-1, name is 2-Chloropyridine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 109-09-1

General procedure: In an oven dried glass tube containing a mixture of pyridine 1a (100 mg, 1.26 mmol), and potassium persulphate (683 mg, 2.53 mmol), formamide 2a (2 ml) was added and the reaction mixture was heated at 70 C. Upon the completion of the reaction (monitored by TLC), saturated sodium bicarbonate solution (5 mL) was added and the crude product was extracted in ethyl acetate (3 X 5 mL). The crude product was purified by column chromatography to furnish compound 3aa as a white crystalline solid (122 mg, 79% yield)

With the rapid development of chemical substances, we look forward to future research findings about 109-09-1.

Reference:
Article; Mete, Trimbak B.; Singh, Ankit; Bhat, Ramakrishna G.; Tetrahedron Letters; vol. 58; 50; (2017); p. 4709 – 4712;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 586-98-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 586-98-1 as follows.

[Methanesulfonic acid pyridin-2-y I methyl ester] (11) To a solution of 2-pyridylcarbinol (10) (300 mg, 2.70 mmol) and triethyl amine (698 mg, 6.75 mmol) in dry THF (10 ml_) at O0C was added a solution of mesylchloride (470 mg, 4.1 mmol) in dry THF (10 ml_). Reaction mixture was allowed to stir for 2 h at room temperature [reaction was followed by TLC]. Reaction mixture was concentrated to remove THF under reduced pressure and the residue was dissolved in CH2CI2 (100 ml_), washed with brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure to give compound 11 (300 mg, 59%) as gum and it was taken as such for next step.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,586-98-1, its application will become more common.

Reference:
Patent; NEUROSEARCH A/S; WO2007/42545; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem