Day: February 4, 2021

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 573762-62-6, name is 5-Amino-3-(trifluoromethyl)picolinonitrile. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 573762-62-6

SM3 (20 g) and MeCN (300 mL) were added into a four-necked round bottom flask equipped with a mechanical stirrer and a thermometer at 20-30 C. under nitrogen followed by cooling to 0-10 C. Thiophosgene (13.7 mL) was added and the mixture was warmed to 20-30 C. After the reaction was completed, the reaction mixture was cooled to 0-10 C. and added saturated NaHCO3 to adjust the pH value to 6-7. The organic layer was separated and concentrated to dryness. The compound of Formula III was obtained (24.93 g) in 100% yield as the brown oil.

With the rapid development of chemical substances, we look forward to future research findings about 573762-62-6.

Reference:
Patent; ScinoPharm Taiwan, Ltd.; Chen, Shang-Hong; Guo, Jiunn-Cheh; Shih, Wen-Li; (12 pag.)US2018/201601; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 113237-20-0, name is 2,6-Dichloro-5-fluoronicotinamide. This compound has unique chemical properties. The synthetic route is as follows. name: 2,6-Dichloro-5-fluoronicotinamide

At RT, 44 g (210.58 mmol) of 2,6-dichloro-5-fluo- ronicotinamide were added to a suspension of2l.9 g (335.35 mmol) of zinc in methanol (207 ml). Acetic acid (18.5 ml) was then added, and the mixture was heated at reflux with stirring for 24 h. The contents of the flask were then decanted from the zinc, ethyl acetate (414 ml) and saturated aqueous sodium bicarbonate solution (414 ml) were added and the mixture was stirred vigorously. The mixture was then filtered off with suction through kieselguhr and washed three times with ethyl acetate (517 ml each). The organic phase was separated off and the aqueous phase was washed with ethyl acetate (258 ml). The combined organic phases were washed once with saturated aqueous sodium bicarbonate solution (414 ml), dried and concentrated under reduced pressure. Dichloromethane (388 ml) was added to the crystals obtained in this manner, and the crystals were triturated for 20 mm. The crystals were once more filtered off with suction and washed with diethyl ether and sucked dry.10414] Yield: 20.2 g (53% of theory) ?H NMR (400 MHz, DMSO-d5): oe=7.87 (br s, 1H),7.99 (dd, 1H), 8.10 (br s, 1H), 8.52 (d, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 113237-20-0, 2,6-Dichloro-5-fluoronicotinamide.

Reference:
Patent; BAYER INTELLECTUAL PROPERTY GMBH; Follmann, Markus; Stasch, Johannes-Peter; Redlich, Gorden; Ackerstaff, Jens; Griebenow, Nils; Knorr, Andreas; Wunder, Frank; Li, Volkhart Min-Jian; Kroh, Walter; Baerfacker, Lars; US2014/350020; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 62068-78-4, Adding some certain compound to certain chemical reactions, such as: 62068-78-4, name is 2,6-Dichloronicotinamide,molecular formula is C6H4Cl2N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 62068-78-4.

6-Chloro-2-propoxy-nicotinamide (2) (1246) To a solution of propan-1-ol (2.94 mL, 39.26 mmol) in DMF (15 mL) at 0 C. was added sodium hydride (95% in mineral oil, 0.94 g, 39.26 mmol) in portions and stirred for 1 h at room temperature. This mixture was slowly added to a solution of 2,6-dichloro-nicotinamide (5.0 g, 26.17 mmol) in DMF (25 mL) at 0 C. The reaction mixture was stirred at room temperature overnight. DMF was removed under reduced pressure, and the resulting mixture was diluted with EtOAc (60 mL), washed with water (2¡Á20 mL) and brine (2¡Á10 mL) solution, dried over anhydrous Na2SO4, filtered, and concentrated to give yellow oil. Purification was accomplished by flash chromatography on silica gel using 5-60% EtOAc/hexanes gradient elution to yield the title compound (3.8 g, 68%) as a transparent oil. 1H NMR (400 MHz, CDCl3) delta ppm 8.46 (d, J=8.2 Hz, 1H), 7.69 (br. s., 1H), 7.06 (d, J=8.2 Hz, 1H), 5.86 (br. s., 1H), 4.48 (t, J=6.6 Hz, 2H), 1.99-1.79 (m, 2H), 1.07 (t, J=7.4 Hz, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 62068-78-4, 2,6-Dichloronicotinamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ANACOR PHARMACEUTICALS, INC.; AKAMA, Tsutomu; US2015/291629; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1539-42-0, name is Bis(pyridin-2-ylmethyl)amine, the common compound, a new synthetic route is introduced below. Computed Properties of C12H13N3

The synthesis followed a modified literature procedure [35]. Amixture of DPA (4.21 g, 20.68 mmol) and triethylamine (4.18 g,41.3 mmol) was dissolved in THF and added dropwise to a solution of 2,6-bis(chloromethyl)-4-methylphenol (2.12 g, 10.3 mmol) in THF at 0C. After the complete addition of the DPA mixture the solution was warmed up to room temperature and left stirring for 4 days. The triethylamine salt precipitate was removed by filtration and washed 3 times with THF, and the combined filtrates were concentrated under vacuum. The residue was dissolved in 50 ml of water and extracted with CH2Cl2 (3¡Á50 ml). The extracts were combined, dried with MgSO4 and the solvent was removed under vacuum. The product was obtained as a yellow oily residue. Yield: 5.24 g (95.6%). 1H NMR (CDCl3): delta 8.42 (4H, m), 7.68 (m, 4H), 7.53 (dd, J=7.8, 3.2, 4H) 7.22 (m, 4H), 6.92 (d,J=3.2, 2H) 3.79 (d, J=3.3, 8H) 3.71 (d, J=3.2, 4H) 2.19 (d,J=3.3, 3H)

The synthetic route of 1539-42-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Bedin, Michele; Agarwala, Hemlata; Marx, Jennifer; Schuenemann, Volker; Ott, Sascha; Thapper, Anders; Inorganica Chimica Acta; vol. 490; (2019); p. 254 – 260;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1289093-31-7, name is 5-Bromo-3-chloro-2-isobutoxypyridine, the common compound, a new synthetic route is introduced below. name: 5-Bromo-3-chloro-2-isobutoxypyridine

To a mixture of 6-fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carbonitrile (step 5) (220 mg, 1.2 mmol) in dioxane (20 ml) was added 5-bromo-3-chloro-2-isobutoxypyridine (intermediate A) (980 mg, 3.7 mmol), CuI (470 mg, 2.5 mmol), K2CO3 (341 mg, 2.5 mmol), and DMEDA (260 mg, 2.5 mmol). After addition, the mixture was degassed and charged with N2 three times. Then the mixture was heated to 110 C. and stirred at that temperature under N2 atmosphere for 16 hrs. When LC/MS indicated the starting material was consumed, the reaction mixture was diluted with DCM (200 ml). The mixture was filtered over celite. The filtration was washed with brine (*3), dried over anhydrous Na2SO4 and filtered. The filtration was evaporated to afford a residue, which was purified by flash column chromatography on silica gel using a gradient 0-20% ethyl acetate in hexanes to afford the title compound as white solid. LC-MS: Rt=1.27 mins; MS m/z [M+H]+ 362.0; Method 5-95AB 1.5minLC_v003 1H NMR (400 MHz, CDCl3) delta 7.96 (1H, d), 7.56 (1H, d), 6.98 (1H, d), 6.22 (1H, d), 4.31 (2H, m), 4.11 (2H, d), 3.68 (2H, m), 2.16 (1H, m), 1.05 (6H, d).

The synthetic route of 1289093-31-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVARTIS AG; CHEN, Shuhui; HE, Haiyang; LAGU, Bharat; QIN, Hua; WU, Chengde; XIAO, Yisong; US2015/183802; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 67346-74-1, Adding some certain compound to certain chemical reactions, such as: 67346-74-1, name is 3-Ethynylpyridin-2-amine,molecular formula is C7H6N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 67346-74-1.

To a tetrahydrofuran (3 mL) solution of (4-phenylamino-phenyl)-acetohydroximoyl chloride (150 mg, 0.576 mmol) described in Manufacturing Example 69-1-4 and 3-ethynyl-pyridin-2-ylamine (43 mg, 0.367 mmol) described in Manufacturing Example 1-2-3 was added triethylamine (201 muL, 1.44 mmol) at room temperature, which was stirred for 7 hours at 50 C. Water was added to the reaction solution at room temperature, which was then extracted with ethyl acetate. The organic layer was washed with water and saturated aqueous sodium chloride, and dried over anhydrous magnesium sulfate. The solvent was evaporated under a reduced pressure. The residue was purified by NH silica gel column chromatography (heptane:ethyl acetate=4:1-2:1) to obtain the title compound (48 mg, 24%). 1H-NMR Spectrum (CDCl3) delta (ppm): 4.00 (2H, s), 5.58 (2H, brs), 5.70 (1H, brs), 6.29 (1H, s), 6.71-6.74 (1H, m), 6.91-6.95 (1H, m), 7.03-7.07 (4H, m), 7.16-7.19 (2H, m), 7.24-7.28 (2H, m), 7.73-7.75 (1H, m), 8.11-8.13 (1H, m).

According to the analysis of related databases, 67346-74-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Eisai R&D Management Co., Ltd.; US2007/105904; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 116026-93-8, tert-Butyl (3-formylpyridin-4-yl)carbamate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: tert-Butyl (3-formylpyridin-4-yl)carbamate, blongs to pyridine-derivatives compound. name: tert-Butyl (3-formylpyridin-4-yl)carbamate

Example 106: (5Z)-5-[(4-aminopyridin-3-yl)methylidene]-2-(piperidin-l-yl)-4,5-dihydro- l,3-thiazol-4-one hydrochloride; (3-Formyl-pyridin-4-yl)-carbamic acid tert-butyl ester (490mg, 1.5mmol), piperidine (0.30 mL, 3.0 mmol), and rhodanine (203mg, 1.5mmol) were added into 10 mL of ethanol in 5OmL flask. The resulting mixture was heated at 75 0C overnight. The solvent was evaporated, 0 and the crude was purified by flash chromatography (0 to 10% MeOH in DCM gradient). 200 mg of [3 -(4-Oxo-2 -piperidin-l-yl-4H-thiazol-5-ylidenemethyl)-pyridin-4-yl]-carbamic acid tert- butyl ester yellow solid was collected as pure product (yield 34%).[3-(4-Oxo-2-piperidin- 1 -yl-4H-thiazol-5-ylidenemethyl)-pyridin-4-yl]-carbamic acid tert- butyl ester (200mg) was dissolved in 5mL of methanolic HCl (4M). The resulting mixture was 5 stirred at room temperature for 2 hours. The solvent was evaporated, and the remaining solid was dried under vacuum to provide desired product (yield 99%). 1H NMR (400 MHz, DMSO- d6) delta 1.67 (m, 6H), 3.5 (m, 2H), 3.90 (m, 2H), 6.97(d, IH), 7.50 (s, IH), 8.13(d, IH), 8.30 (s, IH).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,116026-93-8, tert-Butyl (3-formylpyridin-4-yl)carbamate, and friends who are interested can also refer to it.

Reference:
Patent; CHLORION PHARMA, INC.; WO2009/97695; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 64188-97-2, 3-Aminoisonicotinamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 64188-97-2, blongs to pyridine-derivatives compound. SDS of cas: 64188-97-2

To a suspension of 3-amino-2-carboxamide (1.0 eq) and methyl 2- (chlorocarbonyl)benzofuran-7-carboxylate (1.5 eq) in tetrahydrofuran was added N,N- diisopropylethylamine (3.0 eq) dropwise. The mixture was allowed to stir for 1 hour and concentrated in vacuo to afford methyl 2-((4-carbamoylpyridin-3- yl)carbamoyl)benzofuran-7-carboxylate as a crude product. The residue was used in the next step without further purification

At the same time, in my other blogs, there are other synthetic methods of this type of compound,64188-97-2, 3-Aminoisonicotinamide, and friends who are interested can also refer to it.

Reference:
Patent; DONG-A SOCIO HOLDINGS CO., LTD.; KIM, Myeong-seop; PARK, Taesun; YOON, Taeyoung; YANG, Seung Min; KIM, Hae-Sun; KIM, Jun Gyu; (285 pag.)WO2016/68580; (2016); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 6937-03-7 , The common heterocyclic compound, 6937-03-7, name is Methyl 2-aminoisonicotinate, molecular formula is C7H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Add in the reaction tube0.2 mmol of methyl 2-aminopyridine-4-carboxylate,0.2 mmol of beta-nitrostyrene,lOmol% (0.02 mmol) Ce (OTf) 3, 1.5 ml toluene,After stirring at 120 C for 10 minutes, the heating and stirring were stopped, and the mixture was cooled to room temperature.The crude product is obtained by distillation under reduced pressure and purified by column chromatography.The target product was obtained, and the column chromatography eluent used was a mixture of petroleum ether and ethyl acetate (V:V = 5:1).The yield was 53%. The hydrogen spectrum and carbon spectrum of the product obtained in this example are shown in Fig. 3.The carbon spectrum of the obtained product is shown in Fig. 4.

The synthetic route of 6937-03-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Gannan Normal University; Chen Zhengwang; Ye Min; Zhou Zhonggao; (17 pag.)CN108395399; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 22245-83-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 22245-83-6, name is 3-(Trifluoromethyl)pyridin-2-ol. This compound has unique chemical properties. The synthetic route is as follows.

To a mixture of 2-hydroxy-3-trifluoromethylpyridine 2a1 (39.01 g, 239 mmol) and anhydrous DMF (800 mL) under Ar is added lambda/-iodosuccinimide (4.89 g, 244 mmol) and anhydrous K2CO3 (33.72 g, 244 mmol). The mixture is allowed to stir at 600C for about 3 hours. The mixture is cooled to ambient temperature, filtered and concentrated under reduced pressure. The residue is dissolved in DCM (1 L) and the organic phase is washed with brine. The aqueous phase is adjusted to pH 4 by the addition of 2M HCI, then extracted with DCM (1 L). The combined organic extracts are washed with brine (2 L) and dried over Na2SO4. The mixture is concentrated to ~300 mL and cooled overnight in a fridge. The precipitated solid is removed by filtration and dried to provide iodide 2a2.

According to the analysis of related databases, 22245-83-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GmbH; WO2009/18656; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem