Day: February 19, 2021

Adding a certain compound to certain chemical reactions, such as: 1658-42-0, Methyl 2-(pyridin-2-yl)acetate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1658-42-0, blongs to pyridine-derivatives compound. COA of Formula: C8H9NO2

General procedure: In a reaction tube 66.0 mg (0.4 mmol) of ethyl 2-(pyridin-2-yl)acetate (1a), 41.6 mg (0.2 mmol) of 1,3-diphenyl-2-propenone (2b), 12.65 mg (0.05 mmol) of I2 and 58.4 mg (0.4 mmol) of DTBP were added to 1.0 mL of 1,2-dichlorobenzene and stirred the reaction mixture at 120 ¡ãC, after 24 h of the reaction time, the mixture was allowed to attain room temperature, and quenched the I2 with Na2S2O3 solution, after adding 10 mL of brine solution to reaction mixture, the organic portion was extractedwith ethyl acetate (3×10 mL) and combined organic layers dried over anhydrous Na2SO4, crude mixture obtained after removal of ethyl acetate under reduced presure was purified by column chromatography to isolate 3a with 87 percent yield.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1658-42-0, its application will become more common.

Reference:
Article; Reddy, N. Naresh Kumar; Donthiri, Ramachandra Reddy; Ravi, Chitrakar; Adimurthy, Subbarayappa; Tetrahedron Letters; vol. 57; 30; (2016); p. 3243 – 3246;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 88912-25-8, name is 4,6-Dichloropicolinic acid. A new synthetic method of this compound is introduced below., SDS of cas: 88912-25-8

To a stirred solution of 71 (20.0 g, 104.1 mmol) in CH3OH (200 mL) was charged with conc H2S04 (1.0 mL) at room temperature. The reaction mixture was heated at 70C for 2 h. The reaction mixture was concentrated under reduced pressure, diluted with EtOAc (100 mL) and poured into saturated NaHCO3 solution (80 mL). The layers wereseparated and the aqueous layer was extracted with EtOAc (2450 mL). The combined organic layer was washed with water (100 mL) and brine (100 mL). The organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford 72 [20.0 g (crude)j as a liquid. MS (MM) m/z 207.1 [M + Hj.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 88912-25-8, 4,6-Dichloropicolinic acid.

Reference:
Patent; IOMET PHARMA LTD.; MERCK SHARP & DOHME CORP.; COWLEY, Phillip, M.; WISE, Alan; BROWN, Thomas, J.; MCGOWAN, Meredeth, A.; ZHOU, Hua; HAN, Yongxin; (223 pag.)WO2017/7700; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 151213-42-2, (4aR,7aR)-Octahydro-1H-pyrrolo[3,4-b]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of (4aR,7aR)-Octahydro-1H-pyrrolo[3,4-b]pyridine, blongs to pyridine-derivatives compound. Quality Control of (4aR,7aR)-Octahydro-1H-pyrrolo[3,4-b]pyridine

Compound II (1.26g, 10mmol) and triethylamine (3.04g, 30mmol) was dissolved in 10mL of dry DMF, under stirring and cooling in an ice-water bath, slowly dropwise added triphenylmethyl chloride (TrCl; 3.07g, 11mmol) and 10mL dry DMF solution prepared. After completion of the dropwise addition, the resulting reaction mixture was stirred at room temperature for 3 hours, TLC showed the reaction was complete. The reaction mixture was poured into 120mL ice water, CH2Cl2 (50mL ¡Á 3) the combined extracts were combined, washed with brine, dried over anhydrous sodium sulfate. The desiccant was removed by suction, and the filtrate was evaporated to dryness on a rotary evaporator, the residue obtained was purified by chromatography using a column to give compound III, as a white solid,

The synthetic route of 151213-42-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Foshan Saivs Pharmaceutical Technology Co., Ltd.; Cai, Ziyang; (7 pag.)CN104557928; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 155377-05-2, name is Methyl 6-(trifluoromethyl)picolinate. A new synthetic method of this compound is introduced below., SDS of cas: 155377-05-2

General procedure: Step 2: Preparation of 6-(6-trifluomethylpyridin-2-yl)-1,3,5-triazine-2,4-dione To a solution of freshly prepared NaOEt from Na (3.84 g, 0.16 mol, 3 eq) in ethanol (500 mL) was added methyl 6-trifluoromethylpicolinate (33 g, 0.16 mol, 3 eq) and biuret (5.3 g, 0.052 mol). The resulting mixture was heated to reflux for 1 hr and then concentrated. The residue was poured into water and treated with Sat. aq. NaHCO3 to adjust pH to 7. The precipitated solid was collected by filtration and dried under air to give the desired compound. 1H NMR (400 MHz, DMSO-d6): delta 10.88 (s, 1H), 8.46 (d, J=7.4 Hz, 1H), 8.28 (t, J=7.3 Hz, 1H), 8.11 (d, J=7.4 Hz, 1H). LC-MS: m/z 259 (M+H)+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 155377-05-2, Methyl 6-(trifluoromethyl)picolinate.

Reference:
Patent; AGIOS PHARMACEUTICALS, INC; Konteatis, Zenon D.; Popovici-Muller, Janeta; Travins, Jeremy; Zahler, Robert; Cai, Zhenwei; Zhou, Ding; US2015/18328; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 175205-81-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.175205-81-9, name is 2-Bromo-4-(trifluoromethyl)pyridine, molecular formula is C6H3BrF3N, molecular weight is 225.99, as common compound, the synthetic route is as follows.

n-Butyllithium solution (1.6 M in hexane, 0.46 mL, 0.73 mmol) was added to a flask with diethyl ether (2.0 mL) at ?78 ¡ãC, followed by the dropwise addition of 2-bromo-4-(trifluoromethyl)pyridine (0.10 mL, 0.81 mmol), and the resulting mixture was stirred at -78¡ãC for 45 mm. To the prepared aryllithium solution was added a solution of (4aS,6S)- 1 -(4-fluorophenyl)-6-(( 1-methyl- 1H-pyrazol-4-yl)thio)- 1,4,5,6,7,8-hexahydro-4aH-benzo[flindazole-4a-carbaldehyde (3d) (50 mg, 0.12 mmol) in THF (1.2 mL) dropwise and stirred at ?78 ¡ãC for 30 mm. The reaction was quenched by the addition of water (8 mL). The dry ice bath was removed and the mixture was stirred for 10 mm. Then a small amount of saturated aq. NH4C1 solution was added and the solution was extracted (3 x EtOAc). The combined organic layer was washed (brine), dried (Na2SO4), and concentrated under reduced pressure. Purification of the residue by silica gel column chromatography (12 g Si02, 1percent to 3percent MeOHIDCM, a gradient elution) provided ((4aS,6S)- 1 -(4-fluorophenyl)-6-(( 1-methyl- 1H-pyrazol-4-yl)thio)- 1,4,5,6,7, 8-hexahydro-4aH- benzo [flindazol-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanol (3e) (43 mg, 63percent) as an off-white solid. mlz (ESI, +ve ion) 556.2 [M+Hjb.

Statistics shows that 175205-81-9 is playing an increasingly important role. we look forward to future research findings about 2-Bromo-4-(trifluoromethyl)pyridine.

Reference:
Patent; ORIC PHARMACEUTICALS, INC.; DU, Xiaohui; EKSTEROWICZ, John; FANTIN, Valeria R.; REW, Yosup; SUN, Daqing; YE, Qiuping; ZHOU, Haiying; KAWAI, Hiroyuki; MOORE, Jared; PHAM, Johnny; WU, Kejia; ZHU, Liusheng; YAMASHITA, Dennis; (288 pag.)WO2018/191283; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1480-64-4, name is 3-Chloro-2-fluoropyridine, the common compound, a new synthetic route is introduced below. Quality Control of 3-Chloro-2-fluoropyridine

3-Chloro-2-fluoropyridine (5.00 g, 37.25 mmol, 1 eq.) and benzylamine (5.75 mL, 52.15 mmol, 1.4 eq.) were addedto cesium carbonate (18.21 g, 55.88 mmol, 1.5 eq.) in dimethyl sulfoxide (25 mL) and the reaction mixture wasstirred at 105 C for 7 h. After cooling to 25 C water (25 mL) was added dropwise using an ice bath to maintain thetemperature below 30C. The reaction mixture was transferred to a separation funnel. Then water (15 mL) andethyl acetate (40 mL) were added and the phases were separated. The aqueous phase was extracted with ethylacetate (2 x 50 mL). The combined organic phases were washed with water (4 x 50 mL) and brine (50 mL). Dryingover magnesium sulfate, removal of the solvent and purification by flash chromatography (2 to 3% ethyl acetate inheptanes) gave the N-benzyl-3-chloropyridin-2-amine as a white solid (6.56 g, 81%). Rf = 0.25 (5% ethyl acetate inheptanes).1H NMR (400 MHz, CDCl3): = 1H NMR (400 MHz, CDCl3): = 4.71 (d, J = 5.5 Hz, 2 H), 5.28 (br. s, 1 H), 6.57 (dd, J =7.8, 5.0 Hz, 1 H), 7.27 – 7.32 (m, 1 H), 7.33 – 7.42 (m, 4 H), 7.46 -7.51 (obs. m, 1 H), 8.07 (dd, J = 4.9, 1.6 Hz, 1 H).13C NMR (101 MHz, CDCl3): = 45.5, 113.1, 115.4, 127.3, 127.7, 128.6, 136.1, 139.3, 146.0, 153.9.LC/MS (m/z): [M + H]+ calculated for C12H12ClN2+, 219.1 ; found, 218.7

The synthetic route of 1480-64-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; De Gasparo, Raoul; Lustenberger, Philipp; Mathes, Christian; Schlama, Thierry; Veitch, Gemma E.; Le Paih, Jacques J. M.; Synlett; vol. 25; 9; (2014);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 5349-17-7, 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C7H7Br2NO, blongs to pyridine-derivatives compound. HPLC of Formula: C7H7Br2NO

EXAMPLE 13 [6-CHLORO-3-(1H-1,2,3,4-TETRAZOL-5-YLMETHYL)-1H-INDOL-2-YL](4-PYRIDINYL)METHANONE The title compound was prepared according to the procedure described in step 5 of Example 1 from N-(5-chloro-2-{(E)-2-[1-(2-cyanoethyl)-1H-1,2,3,4-tetrazol-5-yl]ethenyl}phenyl)benzenesulfonamide (Example 1, step 4) and 4-bromoacetylpyridine hydrobromide (L. W. Deady, M. S. Stanborough, Aust. J. Chem., 1981, 34 , 1295). MS (EI) m/z: 338 (M+). IR (KBr) nu: 3246, 2870, 1637, 1526, 1439, 1323, 1248, 943, 841. 1H-NMR (DMSO-d6) delta: 11.92 (1H, s), 8.80 (2H, d, J=4.5 Hz), 7.68 (1H, d, J=8.7 Hz), 7.63 (2H, d, J=4.5 Hz), 7.51 (1H, d, J=1.8 Hz), 7.15 (1H, dd, J=1.8, 8.7 Hz), 4.58 (2H, s).

The synthetic route of 5349-17-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER INC.; EP1065206; (2001); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 851484-95-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 851484-95-2, name is 2-Chloro-5-fluoronicotinaldehyde, molecular formula is C6H3ClFNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In a 250 mL flask, 2-chloro-5-fluoropyridine-3-carboxaldehyde (4. 88 g, 31. 0 mmol) was dissolved in dioxane (103 mL) along with Boc-piperazine (5.77 g, 31. 0 mmol) and potassium carbonate (4.30 g, 31. 0 mmol). The reaction was heated to reflux with stirring for 48 hours. The mixture was then diluted with ethyl acetate (100 mL) and washed with saturated NaHC03 solution (2 x 75 mL) and saturated NaCI solution (2 x 75 mL). The organic layer was collected, dried overanhydrous Na2SO4, and then filtered. Solvent was removed iii vacuo and the residue was purified by column chromatography on silica using 9: 1 hexane/ethyl acetate as the eluent to afford 3. 0g (31%) of the 20a as a yellow solid.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 851484-95-2, 2-Chloro-5-fluoronicotinaldehyde.

Reference:
Patent; NEUROCRINE BIOSCIENCES, INC.; WO2005/40109; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 89364-04-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.89364-04-5, name is 3-Bromo-4-nitropyridine, molecular formula is C5H3BrN2O2, molecular weight is 202.9935, as common compound, the synthetic route is as follows.

Add 200 mL of dioxane to a 500 mL single-necked flask equipped with magnetic stirring at room temperature.Intermediate M99.1g (43.86 mmol, 1 eq),3-bromo-4-nitropyridine 13.2 g (65¡¤81 mmol, 1.5 eq),Potassium carbonate aqueous solution (carbonPotassium acid 18.19g,131.61 mmol, 3 eq,Water 65.8mL, 2M),Tetrakistriphenylphosphine palladium 1 ¡¤ 52g (1 ¡¤ 32mmol, 0 ¡¤ 03eq),Turn on the agitation,Replace the nitrogen 3 times,Warm up to 100C,Reaction overnightThe reaction solution was cooled to room temperature.Extracted with ethyl acetate,Take the upper layer,The reaction solution was sprinkled,Column chromatography separation (eluent: PE: DCM = 2:1),Get a crude product,Boiled with n-hexane,Obtained 16g of a yellow solid.The yield is 58.35%

Statistics shows that 89364-04-5 is playing an increasingly important role. we look forward to future research findings about 3-Bromo-4-nitropyridine.

Reference:
Patent; Beijing Dingcai Technology Co., Ltd.; Gu’an Dingcai Technology Co., Ltd.; Gao Wenzheng; Du Qian; Ren Xueyan; (33 pag.)CN110294760; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 5349-17-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5349-17-7, name is 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide. This compound has unique chemical properties. The synthetic route is as follows.

[0246] 7V-{4-[2-(Dimethylamino)ethoxy]phenyl}-4-(4-pyridinyl)-l,3-thiazol- 2-amine (29). A mixture of bromoketone hydrobromide 1 (0.63 g, 2.25 mmol) and l-(4-(2-(dimethylamino)ethoxy)phenyl)thiourea (28) (0.54 g, 2.25 mmol) in EtOH (20 mL) was stirred at reflux temperature for 2 h. The mixture was cooled to 20 0C, diluted with water (50 mL), the pH adjusted to ca. 8 with aqueous NH3 and the mixture stirred at 0 0C for 1 h. The precipitate was filtered, washed with water (5 mL), and dried. The crude solid was purified by column chromatography, eluting with a gradient (0-20%) of MeOH/EtOAc, followed by 1% aqueous NH3/MeOH/EtOAc, to give amine 29 (447 mg, 58%) as a an oil: 1H NMR delta 10.13 (s, 1 H, NH), 8.60 (dd, J= 4.5, 1.6 Hz, 2 H, H-2′, H-6′), 7.83 (dd, J= 4.5, 1.6 Hz, 2 H, H-3′, H-5′), 7.59-7.64 (m, 3 H, H-5, H-2″, H-6″), 6.95 (ddd, J= 9.0, 3.5, 2.2 Hz, 2 H, H-3″, H-5″), 4.02 (br t, J= 5.9 Hz, 2 H, CH2O), 2.61 (br t, J= 5.9 Hz, 2 H, CH2N), 2.22 [s, 6 H, N(CH3)3]; 13C NMR delta 164.0, 153.4, 150.0 (2), 147.6, 141.0, 134.4, 119.8 (2), 118.7 (2), 114.8 (2), 106.6, 66.0, 57.6, 45.4 (2); MS m/z341.5 (MH+, 100%).

According to the analysis of related databases, 5349-17-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY; AUCKLAND UNISERVICES LIMITED; WO2009/114552; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem