Day: March 2, 2021

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 944937-53-5, name is 6-Bromo-1H-pyrrolo[3,2-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 6-Bromo-1H-pyrrolo[3,2-b]pyridine

To a soution of 6-bromo-1 H-pyrroo[3,2-b]pyridine (300 mg, 1.5 mmo) inDMF (2 mL), at 0 C, was added NaH (183 mg, 4.6 mmoL 60% dispersion in oi?). The reaction mixture was warmed to room temperature and stirred for 10 minutes and then cooed to 0 C and 3-(choromethy 5-methyisoxazoe (240 mg, 1.8 mmo) was added. The mixture was stirred at 0 C for 10 minutes then warmed to room temperature and stirred for 4 hours. Water was addedand the reaction mixture was extracted with EtOAc. The combined organicayers were dried (MgSO4), fi[tered and evaporated. Purification (FCC, Si02,0-100% EtOAc in hexanes) gave the tiUe compound (407 mg, 92%). 1H NMR(400 MHz, DMSO-d6) oe 8.41 (d, J = 2.0 Hz, I H), 8.26 (dd, J = 2.0, 0.9 Hz, I H),7.78 (d, J = 3.4 Hz, I H), 6.64 (dd, J = 3.3, 1.0 Hz, I H), 6.07 (d, J = 1.0 Hz,1 H), 5.52 (s, 2H), 2.33 (d, J = 0.9 Hz, 3H).

With the rapid development of chemical substances, we look forward to future research findings about 944937-53-5.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; CHROVIAN, Christa C.; LETAVIC, Michael A.; RECH, Jason C.; SOYODE-JOHNSON, Akinola; WALL, Jessica L.; (533 pag.)WO2017/7938; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 54916-66-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 54916-66-4, name is 5-Bromo-2-methoxynicotinic acid, molecular formula is C7H6BrNO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 5-bromo-2-methoxynicotinic acid (5 g, 22 mmol) in dichloromethane (75 mL) was treated with Oxalyl dichloride (10 ml) by dropwise at 0 C, then the mixture was stirred at R.T. for 4 hours. A mixture of Ice- H3.H20 was poured into the react solution within an ice-bath and stirred at 0 C for more 10 min and filtered, the filter cake was dried to provide 5-bromo-2-methoxynicotinamide (4.7 g, yield: 94.4%). 1HNMR (400MHz, CDCI3) delta 8.45 (d, J= 2.4 Hz, 1H), 8.20 (d, J= 2.4 Hz, 1H), 7.78 (br, 2H), 3.94 (s, 3H). MS (M+H)+: 231 / 233.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 54916-66-4, 5-Bromo-2-methoxynicotinic acid.

Reference:
Patent; MERCK SHARP & DOHME CORP.; MCCOMAS, Casey Cameron; LIVERTON, Nigel J.; HABERMANN, Joerg; KOCH, Uwe; NARJES, Frank; LI, Peng; PENG, Xuanjia; SOLL, Richard; WU, Hao; PALANI, Anandan; HE, Shuwen; DAI, Xing; LIU, Hong; LAI, Zhong; LONDON, Clare; XIAO, Dong; ZORN, Nicolas; NARGUND, Ravi; WO2013/33971; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 886372-63-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 886372-63-0 as follows.

To a solution of 5-fluoro-6-methoxypyridin-3-amine (0.100 g, 0.704 mmol) in acetone (1 mL) was added dropwise benzoyl isothiocyanate (0. 104 mL, 0.774 mmol). The reaction mixture was all owed to stir at room temperature for 3 h. The reaction mixture was diluted with water and EtOAc. The layers were separated and the organic layer was washed with brine, dried with sodium sulfate, and concentrated under reduced pressure to yield Intermediate 1-21 A (0.215 g, 0.704 mmol, 100 % yield): 1H NMR (400MHz, CDCl3) delta 12,48 (brs, 1H), 9.12 (br s, 1 H), 8,06 (d, 2.0 Hz, 1H ). 8.01 (dd, J=10.8, 2,2 Hz, 1H), 7.91 (d, J=1.1Hz, 1 H), 7.89 (d, J = 1 .5 Hz, 1H), 7.71-7.65 (m, 1H), 7.60-7.54 (m, 2H), 4,06 (s, 3H), LC-MS: method H, RT = 1.18 rnin. MS (ESI) m/z: 306.1 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,886372-63-0, its application will become more common.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; FU, Qinghong; ZHANG, Xiaojun; PRIESTLEY, Eldon Scott; HALPERN, Oz Scott; REZNIK, Samuel Kaye; RICHTER, Jeremy M.; (184 pag.)WO2018/13770; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 33674-96-3, name is (6-Bromopyridin-2-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives

To a solution of (6-bromo-pyridin-2-yl)-methanol (1.5 g, 8.0 mmol) in chloroform (10 mL) was added dropwise sulfuryl choride (1.29 mL, 16 mmol) and the reaction stirred overnight. The reaction was concentrated under reduced pressure to provide a yellow semi-solid. The material was triturated with diethyl ether/hexanes and the solid collected to provide 2-bromo-6-chloromethyl-pyridine (900 mg, 4.37 mmol) as a sticky white solid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 33674-96-3, (6-Bromopyridin-2-yl)methanol.

Reference:
Patent; WYETH; WO2008/73934; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 53014-84-9, name is 2-Methyl-5-formylpyridine. A new synthetic method of this compound is introduced below., Safety of 2-Methyl-5-formylpyridine

EXAMPLE 3 2-[[4-(3-Methoxy-2-pyridyl)butyl]amino]-5-[(6-methyl-3-pyridyl)hydroxymethyl]-4-(1H)-pyrimidinone 2-[[4-(3-Methoxy-2-pyridyl)butyl]amino]-4-(1H)-pyrimidinone (1.42 g, 0.005 mol) was dissolved in concentrated hydrochloric acid (10 ml) and 2-methyl-5-formylpyridine (1.35 g, 0.012 mol) was added. The solution was stirred at reflux temperature for 24 hours, cooled, basified with 10N sodium hydroxide to pH 8.5 and the product left to separate as an oil. The aqueous mother liquor was decanted and the oil subjected to medium pressure liquid chromatography (Kieselgel 60, 230-400 mesh) with methanolic ammonia: dichloromethane (10:90) as eluent. The relevant fractions were combined and evaporated under reduced pressure to afford the title compound (0.63 g). Crystallisation from aqueous methanol afforded the title product as a white crystalline solid, m.p. 82 C.; delta(CDCl3) 1.6 (4H, m), 2.5 (3H, s) 2.75 (2H, m), 3.3 (2H, m), 3.8 (3H, s), 5.7 (1H, s), 7.1 (3H, m), 7.4 (1H, s), 7.65 (1H dd), 7.9 (1H, dd), 8.5 (1H, m) ppm.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 53014-84-9, 2-Methyl-5-formylpyridine.

Reference:
Patent; Smith Kline & French Laboratories Limited; US4569996; (1986); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 136888-21-6, 2-Chloro-5-fluoro-3-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C5H2ClFN2O2, blongs to pyridine-derivatives compound. Computed Properties of C5H2ClFN2O2

Diethyl malonate (9.98 g, 62.3 mmol) was diluted in DMF (50 ml), to which was then added 60 wt%sodium hydride (2.266 g, 56.6 mmol) under ice cooling, and the resulting mixture was stirred under ice cooling and at room temperature. After that, a solution of Compound 33 (5.00 g, 28.3 mmol) dissolved in DMF (5 ml) was added to the reaction mixture under ice cooling, and the resulting mixture was stirred at room temperature. After completion of the reaction, ethyl acetate was added to the reaction mixture under ice cooling, and the resulting mixture was washed with 2 mol/L aqueous solution of hydrochloric acid and with water. The obtained organic layer was dried over magnesium sulfate, and then the solvent was removed by concentration under reduced pressure. The obtained residue was purified by silica gel column chromatography. About 80% portion of the purified product was diluted in DMSO (50 ml), to which were then added water (0.5 ml) and lithium chloride (4.86 g, 115 mmol), and the resulting mixture was stirred at 110C. After completion of the reaction, a mixed solvent of ethyl acetate and hexane was added to the reaction mixture, from which insoluble materials were removed, and which was then washed with water. The obtained organic layer was dried over magnesium sulfate, and then the solvent was removed by concentration under reduced pressure. The obtained residue was purified by silica gel column chromatography to obtain Compound 122 (2.98 g). Compound 122; Method B LC/MS retention time = 1.65 min. MS (ESI) m/z = 229.15(M+H)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,136888-21-6, 2-Chloro-5-fluoro-3-nitropyridine, and friends who are interested can also refer to it.

Reference:
Patent; Shionogi & Co., Ltd.; TAMURA, Yuusuke; HINATA, Yu; KOJIMA, Eiichi; OZASA, Hiroki; (241 pag.)EP3187498; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 73870-24-3, 4-(Bromomethyl)pyridine hydrobromide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 73870-24-3, blongs to pyridine-derivatives compound. SDS of cas: 73870-24-3

Will contain compound 16 (150 mg, 0.386 mmol), Potassium carbonate (138 mg, 1.0 mmol), 4-bromomethylpyridine hydrobromide (102 mg, 0.403 mmol) the mixture with DMF (5 mL) was stirred at room temperature overnight.Water (20 mL) was added and extracted with ethyl acetate (20 mL¡Á3).The combined organic phases were washed sequentially with water (15 mL) and brine (15 mL). Dry over anhydrous sodium sulfate. Evaporate the solvent under reduced pressure.The product is purified by column chromatography (200-300 mesh silica gel,Ethyl acetate: dichloromethane = 1:1 to 10:1 elution),2-[4-Methoxy-3-(pyridin-4-ylmethoxy)-phenyl]-5,7-bis(methoxymethoxy)-4H-benzopyran-4-one (17) (144 mg).The yield was 77.8%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,73870-24-3, 4-(Bromomethyl)pyridine hydrobromide, and friends who are interested can also refer to it.

Reference:
Patent; Jiangsu Xin Element Pharmaceutical Technology Co., Ltd.; Shi Dongfang; Fu Changjin; Cheng Xi; Gong Weiwei; Gu Jie; Zhang Min; Li Pengfei; Yang Yan; Jin Wenqing; (57 pag.)CN110294732; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.78607-32-6, name is 3-Amino-2,5-dichloropyridine, molecular formula is C5H4Cl2N2, molecular weight is 163.0047, as common compound, the synthetic route is as follows.Safety of 3-Amino-2,5-dichloropyridine

A mixture of trimethylchlorosilane and 1,2-dibromoethane (7:5 v/v, 0.125 ml) was added dropwise (keeping the T¡ãC below 50¡ãC) to a suspension of zinc powder (422 mg) in dimethylacetamide (3 ml). The mixture was stirred 20 min at room temperature then a solution of l-(t-butoxycarbonyl)-4-iodo-piperidine (1.62 g, prepared in 2 steps from l-(t-butoxycarbonyl)-piperidin-4-one according to J. Org. Chem. 2004, 5120) indimethylacetamide (3 ml) was added dropwise over 5 min (slightly exothermic). The resulting mixture was stirred at room temperature for 30 min then cannulated into a mixture of 2,5-dichloro-3-aminopyridine (603 mg), copper(I) iodide (42 mg) and PdCl2(dppf) (91 mg) in dimethylacetamide (5 ml). The resulting mixture was stirred at 80¡ãC for 3 hours, cooled to room temperature, poured into water, extracted with ethyl acetate, dried over sodium sulfate and concentrated in vacuo. The residue was subjected to silica gel chromatography (ethyl acetate: cyclohexane 3:7) to afford 3-amino-5-chloro-3′,6′-dihydro-2’H-[2,4′]bipyridinyl-r-carboxylic acid tert-butyl ester (535 mg) as a yellow solid. *H NMR (400 MHz, CDC13) 1.4 (s, 9H), 1.8 (m, 4H), 2.6 (m, 1H), 2.8 (m, 2H), 3.7 (br s, 2H), 4.2 (m, 2H), 6.9 (s, 1H), 7.9 (s, 1H).The product thus obtained (448 mg) was treated as described in Example 1, Steps D and E to afford the title product (455 mg) as a white solid. M.p. 63-67 ¡ãC; *H NMR (400 MHz, CDCI3) 1.9 (m, 2H), 2.2 (m, 4H), 2.7 (m, 1H), 3.2 (m, 2H), 3.3 (m, 2H), 6.2 (dt, J = 18, 9 Hz, 1H), 6.5 (d, J = 18 Hz, 1H), 7.1-7.3 (m, 4H), 7.7 (d, J = 5.2 Hz, 1H), 7.8 (s, 1H), 7.9 (m, 1H, NH), 8.3 (d, J = 2.4 Hz, 1H), 8.4 (d, J = 2.4 Hz, 1H), 8.6 (d, J = 4.8 Hz, 1H), 8.7 (d, J = 5.5 Hz, 1H); Retention Time HPLC 1.53 min; MS (ES+) 501/503/505 (M+H+).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,78607-32-6, 3-Amino-2,5-dichloropyridine, and friends who are interested can also refer to it.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; WO2006/3494; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 101990-73-2, name is 2-Chloro-4-(chloromethyl)pyridine. A new synthetic method of this compound is introduced below., Recommanded Product: 101990-73-2

To a solution of ethyl 5-methyl-lH-l ,2,4-triazole-3-carboxylate (50 mg, 0.28 mmol) and 2-chloro-4-(chloromethyl)pyridine (50 mg, 0.31 mmol) in DMF (2 mL), K2CO3 (116 mg, 0.84mmol) was added. The mixture was stirred at RT overnight, and was then diluted with H20 (20 mL), extracted with EtOAc (3 x 20 mL), 4: 1 CHCl3: PrOH (3 x 20 mL), dried with MgS04 and concentrated under reduced pressure. The crude product was purified on a Biotage pre-packed silica gel column (EtOAc:Hexane 12% to 100% EtOAc) to afford ethyl l-((2- chloropyridin-4-yl)methyl)-5-methyl-lH-l ,2,4-triazole-3-carboxylate (29 mg, 40%) as a white solid. MS(ES+) Ci2H13ClN402 requires: 280 found: 281 [M+H]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 101990-73-2, 2-Chloro-4-(chloromethyl)pyridine.

Reference:
Patent; JONES, Philip; DIFRANCESCO, Maria, Emilia; PETROCCHI, Alessia; CARROLL, Christopher, L.; MARSZALEK, Joe; CZAKO, Barbara; JOHNSON, Ryan; THEROFF, Jay; WO2014/31936; (2014); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 6515-38-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6515-38-4, name is 3,5,6-Trichloropyridin-2(1H)-one. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 4 PREPARATION OF O-(3,5,6-TRICHLORO-2-PYRIDYL) ETHYLPHOSPHONOCHLORIDOTHIONATE 3,5,6-Trichloro-2-hydroxypyridine (9.15 grams; 0.05 mole) and 100 ml of benzene were charged into a glass reaction vessel fitted with a mechanical stirrer and thermometer and the mixture cooled to about 10 C. Triethylamine (5.05 grams; 0.05 mole) was added. The resulting mixture was cooled to 5 C. and ethylphosphonothionic dichloride (8.19 grams; 0.05 mole) dissolved in 10 ml of benzene was added dropwise, with stirring, at this temperature. Stirring was continued for 1 hour at 5 C. The mixture was allowed to warm to room temperature, held an additional 0.5 hour at room temperature, then filtered. The filtered-off solids were washed with benzene and the washings combined with filtrate. The desired product O-(3,5,6-trichloro-2-pyridyl) ethylphosphonochloridothionate was not isolated but was left in solution for further reaction.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6515-38-4, 3,5,6-Trichloropyridin-2(1H)-one.

Reference:
Patent; Velsicol Chemical Corporation; US4226859; (1980); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem