Day: March 18, 2021

Related Products of 1201924-31-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1201924-31-3, name is 6-Chloro-3-methylpicolinonitrile. This compound has unique chemical properties. The synthetic route is as follows.

To a round bottom flask is added 3-methyl-l-oxo-pyridine-2- carbonitrile (16.2 g, 120.77 mmoles), toluene (8 mL), and phosphoryl chloride (16.83 mL; 181.2 mmoles). The mixture is stirred at 90 C for 90 minutes, cooled to RT, and added dropwise to aqueous 2M KH2PO4 (483 mL; 966 mmoles). The mixture is stirred 30 minutes, and the layers are separated. The organic layer is dried over MgS04, filtered, and concentrated to 6-chloro-3-methyl-pyridine-2-carbonitril: Mass spectrum (m/z): 153.0 (M+H)+. Phenylboronic acid (17.94 g, 144.9 mmoles), toluene (130 mL), sodium carbonate (190.2 g, 362.31 mmoles), bis(triphenylphosphine)palladium(II) chloride (856 mg; 1.21 mmoles) are added to this crude material. The mixture is stirred at 80C for 1 hour and cooled to RT. The layers are separated, and the organic layer is dried over MgS04, filtered, and concentrated. The material was purified by silica gel chromatography (400 g ISCO cartridge) using methylene chloride in hexanes from 20 to 100% to afford 3-methyl-6-phenyl-pyridine-2-carbonitrile (6.7 g, 28.6%). Mass spectrum (m/z): 195.1 (M+H)+.

According to the analysis of related databases, 1201924-31-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ELI LILLY AND COMPANY; BLANCO-PILLADO, Maria-Jesus; MANNINEN, Peter Rudolph; SCHIFFLER, Matthew Allen; VETMAN, Tatiana Natali; WARSHAWSKY, Alan M.; YORK, Jeremy Schulenburg; WO2015/94912; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 82205-58-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 82205-58-1, name is 1-(5-Nitropyridin-2-yl)piperazine. A new synthetic method of this compound is introduced below.

(General acetylation/sulphonylation procedure). Compound 3b (208 mg, 1 mmol), acetyl chloride (79 mul, 1.1 mmol) and PS-NMM (100 mg) in CH2Cl2 (5 mL) were stirred for 16 h. After adding PS-Trisamine (150 mg) to the reaction mixture was left to stir for a further 2 h, filtered and concentrated in vacuum to afford a yellow solid: 250 mg (90%) yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,82205-58-1, 1-(5-Nitropyridin-2-yl)piperazine, and friends who are interested can also refer to it.

Reference:
Article; Spencer, John; Patel, Hiren; Callear, Samantha K.; Coles, Simon J.; Deadman, John J.; Tetrahedron Letters; vol. 52; 45; (2011); p. 5905 – 5909;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 65156-94-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 65156-94-7, name is 5-Chloro-1H-pyrrolo[3,2-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 5-chloro-lH-pyrrolo[3,2-b]pyridine (450 mg, 2.95 mmol, 1 equiv), Cs2C03 (960.9 mg, 2.95 mmol, 1 equiv) and iodomethane (418.6 mg, 2.95 mmol, 1.000 equiv) in DMF (11.2 mL), was stirred for 4 h at 60 C. The reaction was quenched by the addition of 30 mL of water, extracted with 10 ml of ethyl acetate and the combined organic layers concentrated under reduced pressure. The residue was purified by silica gel chromatography with ethyl acetate/petr oleum ether (1 : 10) as eluent to afford the desired final product as a yellow oil in 81% yield.

According to the analysis of related databases, 65156-94-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; IDEAYA BIOSCIENCES, INC.; ALAM, Muzaffar; BECK, Hilary Plake; DILLON, Michael Patrick; GONZALEZ-LOPEZ, Marcos; RICO, Alice Chen; SUTTON, JR., James Clifford; (317 pag.)WO2019/18562; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 89402-43-7, name is 5-Chloro-2,3-difluoropyridine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 89402-43-7

To a solution of compound 1 (1 g, 6.687mmol, 1 eq) in Dry Methanol (5ml_), a solution of 30% NaOMe (1 .8ml_, 10.03mmol, 1.5eq) was added dropwise and the reaction mixture was heated to 65C for 2h (Reaction was monitored by 1 HNMR and LCMS). Then, the reaction mixture was cooled to RT and concentrated under reduced pressure to give a residue. Residue was dissolved in EtOAc and washed with water. The separated organic layer was dried over Na2S04 and concentrated under reduced pressure to give compound 2 (750mg, 69.89%) as colorless liquid; which was sufficiently pure to use for next step.

With the rapid development of chemical substances, we look forward to future research findings about 89402-43-7.

Reference:
Patent; ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR); AL-AWAR, Rima; ISAAC, Methvin; CHAU, Anh My; MAMAI, Ahmed; WATSON, Iain; PODA, Gennady; SUBRAMANIAN, Pandiaraju; WILSON, Brian; UEHLING, David; PRAKESCH, Michael; JOSEPH, Babu; MORIN, Justin-Alexander; (441 pag.)WO2019/153080; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 73896-36-3 ,Some common heterocyclic compound, 73896-36-3, molecular formula is C6H7N3O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

B. 6-Bromo-3-nitro-pyridin-2-ylamine. To a glass pressure vessel containing 6-methoxy-3-nitro-pyridin-2-ylamine (5.0 g, 29.5 mmol) was added 30% hydrogen bromide/acetic acid (60 mL). The vessel was sealed, and the contents were heated to 60 C. for 24 h. The reaction mixture was cooled, and the solvent was removed in vacuo giving 6.8 g (>95%) of crude 6-amino-5-nitro-pyridin-2-ol hydrobromide (HPLC: Rt=5.46). This material (2.0 g, 8.5 mmol) was taken up in toluene (30 mL), followed by phosphorus pentoxide (2.4 g, 17.0 mmol) and tetrabutyl ammonium bromide (3.2 g, 9.7 mmol). The mixture was heated to reflux for 4 h. The reaction mixture was cooled to 0 C., diluted with saturated NaHCO3, and extracted with ethyl acetate (3*100 mL). The combined organics were washed with water (100 mL) and dried (Na2SO4) to afford 1.18 g (64%) of 6-bromo-3-nitro-pyridin-2-ylamine. HPLC: Rt=8.17. 1H NMR (400 MHz, DMSO-d6): 8.33 (br s, 2H), 8.32 (d, J=8.6 Hz, 1H), 6.96 (d, J=8.6 Hz, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,73896-36-3, its application will become more common.

Reference:
Patent; Arienti, Kristen L.; Axe, Frank U.; Breitenbucher, J. Guy; Huang, Liming; Lee, Alice; McClure, Kelly J.; US2003/176438; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 67346-74-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 67346-74-1, name is 3-Ethynylpyridin-2-amine, molecular formula is C7H6N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Manufacturing Example 1-4-1: Di-tert-butyl (3-ethynylpyridin-2-yl)imide dicarbonate; 3-Ethynyl-pyridin-2-ylamine (6.34 g) described in Manufacturing Example 1-2-3 of International Publication WO 07/052,615, di-tert-butyl dicarbonate (58.5 g), triethylamine (27.1 g), 4-dimethylaminopyridine (655 mg), and tetrahydrofuran (254 mL) were stirred for 18 hours at room temperature. Silica gel was added to the reaction solution, and the solvent was concentrated under a reduced pressure. The silica gel thus obtained was purified by silica gel chromatography (heptane:ethyl acetate=3:1) to obtain the title compound (15 g) as a white solid.1H-NMR spectrum (DMSO-d6) delta (ppm): 1.32 (18H, s), 4.59 (1H, s), 7.39-7.44 (1H, m), 7.99-8.03 (1H, m), 8.46-8.48 (1H, m).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 67346-74-1, 3-Ethynylpyridin-2-amine.

Reference:
Patent; Eisai R&D Management Co. Ltd.; US2009/233883; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 93683-65-9 ,Some common heterocyclic compound, 93683-65-9, molecular formula is C6H2ClN3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 6-chloro-3-nitropyridine-2-carbonitrile (0.32 g) and concentrated hydrochloric acid (1.2 mL) in ethanol (3.6 mL) was added iron powder (0.34 g) at room temperature and the mixture was heated to reflux 30 minute. After the reaction mixture was cooled to room temperature, saturated sodium hydrogencarbonate water was added to make the reaction alkaline. After the addition of ethyl acetate, the mixture was filtered through celite and the filtrate was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was concentrated under reduced pressure to give the title compound (0.24 g

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 93683-65-9, 6-Chloro-3-nitropicolinonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; KISSEI PHARMACEUTICAL CO., LTD.; SHIMIZU, KAZUO; MIYAGI, TAKASHI; OHNO, KOHSUKE; UENO, YASUNORI; ONDA, YUSUKE; SUZUKI, HIKARU; (70 pag.)TW2016/5823; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 874959-68-9, Adding some certain compound to certain chemical reactions, such as: 874959-68-9, name is 5-Bromopyridine-2-sulfonyl chloride,molecular formula is C5H3BrClNO2S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 874959-68-9.

[(2,2-Dimethyl-1 ,3-dioxolan-4-yl)methyl]amine (0.76ml, 5.85mmol), 5-bromo-2- pyridinesulfonyl chloride (1g, 3.9mmol), DIPEA (1.3ml, 7.8mmol), were stirred together in DCM (20ml) at room temperature under N2 for 1 h. The reaction mixture was extracted with sodium bicarbonate (20ml) dried on a phase separator and reduced under vacuum to give the title compound as a yellow solid ( 0.629g) MH+ 351/353, rt = 2.58 min

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 874959-68-9, 5-Bromopyridine-2-sulfonyl chloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXO GROUP LIMITED; WO2008/145688; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 93683-65-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 93683-65-9, name is 6-Chloro-3-nitropicolinonitrile. A new synthetic method of this compound is introduced below.

beta-chloro-S-nitro-pyridine-l-carbonitrile (100 mg, 0.54 mmol) is taken up in EtOH (1 niL), combined with SnCl2 (413 mg, 2.18 mmol) and heated to 900C for 3 h. Then the solvent is removed, the residue is taken up in ethyl acetate and first of all washed with NaHCO3 to pH 7, then washed with NaOH (2 M) to pH 8-9. Then the residue is filtered throughCelite, the filtrate is extracted again with ethyl acetate and the combined organic phases are dried on Na2SO4. The solvent is eliminated in vacuo and 3-amino-6-chloro-pyridine-2- carboxylic acid amide is obtained (HPLC-MS: tRet. = 0.78 min, MS(M+H)+ = 172, method LCMSBASl).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,93683-65-9, its application will become more common.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ENGELHARDT, Harald; BOEHMELT, Guido; KOFINK, Christiane; KUHN, Daniel; MCCONNELL, Darryl; STADTMUELLER, Heinz; WO2010/7116; (2010); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 116118-99-1, 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C8H10ClNO2S, blongs to pyridine-derivatives compound. Formula: C8H10ClNO2S

Synthesis Example 16c 4,5,6,7-Tetrahydro-thieno[3,2-c]pyridine 4,5,6,7-Tetrahydro-thieno[3,2-c]pyridine-2-carboxylic acid hydrochloride (260 mg, 1.2 mmol) was mixed with 47% hydrogen bromide aqueous solution (3 ml) and heated under reflux for 4 hours. The reaction solution was returned to room temperature and alkalified by adding sodium hydroxide aqueous solution (5 N), and the reaction product was extracted with diethyl ether, washed with saturated brine and then dried with anhydrous magnesium sulfate. By evaporating the solvent from the organic layer under a reduced pressure, 160 mg (1.1 mmol, 95% in yield) of the title compound was obtained. 1H-NMR (CDCl3): delta 2.80 (2H, t, J=5.6 Hz), 3.15 (2H, t), 3.93 (2H, t, J=1.7 Hz), 6.74 (1H, d, J=5.1 Hz), 7.07 (1H, d); MW 139.22 (C7H9NS); Mass spectrum EI-MS m/z 139 (M)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,116118-99-1, 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid hydrochloride, and friends who are interested can also refer to it.

Reference:
Patent; Meiji Seika Kaisha, Ltd.; US6498251; (2002); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem