Day: May 31, 2021

Synthetic Route of 571188-59-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 571188-59-5 as follows.

General procedure: To a solution of alcohol (1.1 mmol) in a mixture of solvents EtOAc: DMSO (4 ml: 2 ml), was added T3P (2.5 mmol, 50% solution in ethyl acetate) at 0 C, and the resulting mixture was stirred at room temperature for 1-2 h under nitrogen atmosphere. The reaction was monitored by TLC, amine (1.0 mmol) and thioglycolic acid (1.0 mmol) were added once and stirred further for 1-3 h at room temperature. After completion of the reaction, the mixture was diluted with water (20 ml) and neutralized by adding 10% NaHCO3 solution. The product was extracted with ethyl acetate (10 ml 2) and the combined organic layers were washed with water followed by brine solution. The organic phase was dried over anhydrous Na2SO4. The solvent was removed under reduced pressure to afford a crude product which was purified by column chromatography using hexane: ethyl acetate mixture (8:2) as an eluent.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,571188-59-5, its application will become more common.

Reference:
Article; Sharath Kumar, Kothanahally S.; Swaroop, Toreshettahally R.; Harsha, Kachigere B.; Narasimhamurthy, Kereyagalahally H.; Rangappa, Kanchugarakoppal S.; Tetrahedron Letters; vol. 53; 42; (2012); p. 5619 – 5623;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 157329-89-0, name is 2-Bromo-6-chloro-4-methylpyridine, molecular formula is C6H5BrClN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 157329-89-0

b) 4-Methyl-2,6-bis-(4-trifluoromethylphenyl)-pyridine To a degassed solution of 2-bromo-6-chloro-4-methyl-pyridine (1.45 g, 7.04 mmol), 4-trifluoromethylbenzeneboronic acid (3.8 g, 20 mmol), 2N Na2CO3 (10 mL) in DME (80 mL) was added tetrakis(triphenylphosphine)palladium (690 mg, 0.6 mmol) under argon. The mixture was heated to 85 C. for 4 h, cooled to room temperature, diluted with water, and extracted with methylene chloride (3*). The organic solution was washed with brine, dried over Na2SO4, and concentrated. The residue was purified by column chromatography on silica gel (0-20% methylene chloride in heptane) to give the product as an off white solid (1.75 g, 65%). 1H NMR (300 MHz, CDCl3) delta 8.24 (d, J=7.91 Hz, 26H), 7.75 (d, J=8.29 Hz, 26H), 7.61 (s, 13H), 2.53 (s, 19H). MS m/e 382.2 (M+H)

With the rapid development of chemical substances, we look forward to future research findings about 157329-89-0.

Reference:
Patent; Lu, Tianbao; US2010/22583; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 73335-64-5, name is 1-(5-Bromopyridin-3-yl)-N-methylmethanamine. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 1-(5-Bromopyridin-3-yl)-N-methylmethanamine

Step B Tert-butyl((5-bromopyridin-3-yl)methyl)(methyl)carbamate (31b)To a stirred solution of 31a (1 g, 4.97 mmol) in methanol (10 mL) triethylamine (3.3 mL, 24.8 mmol ) was added at 0C followed by the drop wise addition of Boc anhydride (1.7 mL, 7.5 mmol). The reaction mixture was stirred overnight at room temperature under nitrogen atmosphere. The reaction mixture was concentrated under reduced pressure. The residue was diluted with ethyl acetate, successively washed with water and brine. The organic layer was dried over anhydrous Na2SO4, evaporated to dryness under reduced pressure to obtain 31b (800 mg) as colorless gummy mass. 1H NMR (400 MHz, CD3OD): delta 8.59 (d, J=1.80 Hz, 1H), 8.43 (d, J=1.50 Hz, 1H), 7.92 (t, J=2.00 Hz, 1H), 4.47 (s, 2H), 2.91 (s, 3H), 1.46 (s, 9H). Molecular Formula: C12H17Br2O2; LC- MS purity: 98.4%; Expected: 301.1; Observed: 301.1 (M).

With the rapid development of chemical substances, we look forward to future research findings about 73335-64-5.

Reference:
Patent; MERCK SHARP & DOHME CORP.; BARR, Kenneth, Jay; SCOTT, Mark, E.; THOMPSON, Christopher, F.; ANTHONY, Neville; CAMMARANO, Carolyn, Michelle; BAKSHI, Raman, Kumar; MOHANTY, Subhendu, Kumar; KORAPALA, Chandra, Sekhar; LATTHE, Prashant, R.; KAMBAM, Vyjayanthi, N.; SARKAR, Sujit, Kumar; THATAI, Jayanth, Thiruvellore; WO2015/50798; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 887147-19-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 887147-19-5 as follows.

General procedure: Similar to as described in General Procedure U, 4,6-dichloro-1-methyl-1H-imidazo[4,5-c]pyridine was reacted with potassium(R)-trifluoro(3 -((3-hydroxy- 1 -methyl-2-oxopyrrolidin-3-yl)ethynyl)phenyl)borate to give the titlecompound (80 mg, 20%) as a yellow solid. LC-MS (ES, m/z): 381 [M+H]. A tube containing a solution of arylchloride/bromide (1 eq) and aryltrifluoroborate (1 eq) in Ethanol was purged with nitrogen before addition of Pd(OAc)2 (0.06 eq), RuPhos (0.12 eq), and Sodium Carbonate (2 eq). The tube was sealed with a cap lined with a disposable Teflon septum was heated at 85 C for 12-20 hours. The reaction mixture was allowedto cool to room temperature and was either filtered through Celite and submitted directly to reverse phase HPLC purification or extracted with dichloromethane and a solution of saturated ammonium chloride before drying, evaporating and submitting to reverse phase purification or using in the subsequent step without purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,887147-19-5, its application will become more common.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BLAQUIERE, Nicole; BURCH, Jason; CASTANEDO, Georgette; FENG, Jianwen A.; HU, Baihua; LIN, Xingyu; STABEN, Steven; WU, Guosheng; YUEN, Po-wai; WO2015/25026; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 13534-98-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 13534-98-0, name is 4-Amino-3-bromopyridine. A new synthetic method of this compound is introduced below.

To a lOOmL reaction flask was added 3-bromo-4-amino-pyridine (1.73 g, lOmmol), p-fluorobenzeneboronic acid (1.68 g, 12 mmol), anhydrous sodium carbonate (1.59 g, 15 mmol), dioxane (20 mL), and water (10 mL) were replaced with nitrogen, The reaction was carried out for about 3 hours. After completion of the reaction, water (20 mL) was added, extracted three times with ethyl acetate (3 X 20 mL), and the mixture was stirred at room temperature The layers were combined, dried over anhydrous sodium sulfate, filtered and steamed off Column 31 (1.738) yield 92% yield. ]

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13534-98-0, 4-Amino-3-bromopyridine, and friends who are interested can also refer to it.

Reference:
Patent; Chengdu Haichuang Pharmaceutical Co., Ltd.; Fan Lei; Du Wu; Li Xinghai; Chen Yuanwei; Xu Kexin; Chen Ke; Zhang Shaohua; Luo Tongchuan; (40 pag.)CN106831556; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 68470-59-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.68470-59-7, name is 2-(Bromomethyl)-6-methylpyridine, molecular formula is C7H8BrN, molecular weight is 186.0491, as common compound, the synthetic route is as follows.

Step B: Preparation of 3 -iodo- 1 -((6-methylpyridin-2-yl)methyl)-4-nitro- 1 H- indazole: To a solution of 3-iodo-4-nitro-lH-indazole (172 mg, 0.596 mmol) in dry DMF (3 mL) under an atmosphere of dry nitrogen was added 2-(bromomethyl)-6-methylpyridine (122 mg, 0.656 mmol) and potassium carbonate (165 mg, 1.19 mmol) with stirring. The mixture was stirred at ambient temperature for 3 days. The reaction mixture was diluted with water (20 mL) and extracted into ethyl acetate. The organic phases were combined, washed with saturated sodium chloride solution, dried over sodium sulfate, filtered and concentrated under reduced pressure. The resulting material was purified using preparative chromatography on silica, eluting with hexane/ethyl acetate (3: 1) to give 3-iodo-l-((6-methylpyridin-2- yl)methyl)-4-nitro-lH-indazole (213 mg).

Statistics shows that 68470-59-7 is playing an increasingly important role. we look forward to future research findings about 2-(Bromomethyl)-6-methylpyridine.

Reference:
Patent; ARRAY BIOPHARMA INC.; BOYS, Mark Laurence; DELISLE, Robert Kirk; HICKEN, Erik James; KENNEDY, April L.; MARESKA, David A.; MARMSATER, Fredrik P.; MUNSON, Mark C.; NEWHOUSE, Brad; RAST, Bryson; RIZZI, James P.; RODRIGUEZ, Martha E.; TOPALOV, George T.; ZHAO, Qian; WO2012/82689; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 55304-75-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 55304-75-1, name is 2,6-Dichloro-3-(trifluoromethyl)pyridine, molecular formula is C6H2Cl2F3N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A suspension of 3-(R)-methyl-1-trityl-piperazine (from Example 4; 7.80 g, 22.9 mmol), 2,6-dichloro-3-trifluoromethylpyridine (4.50 g, 20.8 mmol) and K2CO3 (4.0 g, 29 mmol) in DMSO (100 mL) was stirred at 80 C. over night. A mixture of EtOAc/toluene (50:50; 500 mL) was added to the filtered solution and the mixture were washed three times with water (1 L). The dried (MgSO4) organic phase was concentrated under reduced pressure and the resulting brown oil was dissolved in heptane/EtOAc (90:10) and filtered through a plug (6060 mm) of silica. Slow evaporation of about two thirds of the solvent at reduced pressure afforded light yellow crystals (6.11 g, 56%). Purity 100% (HPLC); mp 209 C. Fragmenting MS analysis supports the stated structure. Anal. (C30H27ClF3N3) C, H, N.

According to the analysis of related databases, 55304-75-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Nilsson, Bjorn M.; Ringberg, Erik; US2003/232814; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1072-97-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1072-97-5, name is 5-Bromopyridin-2-amine. A new synthetic method of this compound is introduced below.

Step 1 – Synthesis of 6-bromoimidazo[l,2-] yridine [0251] To a solution of 5-bromopyridin-2-amine (2 g, 11.6 mmol) in ethanol (20 mL) was added 2-chloroacetaldehyde (2.00 g, 25.5 mmol) at room temperature and heated to reflux overnight. The reaction was cooled and concentrated and the resulting solid diluted with saturated sodium bicarbonate and extracted twice with ethyl acetate. The combined organic layers were dried over anhydrous sodium sulfate and concentrated to afford 6- bromoimidazo[l,2-a]pyridine as a brown solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1072-97-5, 5-Bromopyridin-2-amine, and friends who are interested can also refer to it.

Reference:
Patent; MERCK SHARP & DOHME CORP.; LYCERA CORPORATION; AICHER, Thomas D.; VAN HUIS, Chad A.; MACLEAN, John K.; ANDRESEN, Brian M.; BARR, Kenneth J.; BIENSTOCK, Corey E.; ANTHONY, Neville J.; DANIELS, Matthew; LIU, Yuan; WHITE, Catherine M.; LAPOINTE, Blair T.; SCIAMMETTA, Nunzio; SIMOV, Vladimir; TROTTER, Wesley, B.; LIU, Kun; WO2015/95788; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1028-86-0, Adding some certain compound to certain chemical reactions, such as: 1028-86-0, name is N-(2-Chloropyridin-3-yl)-2-nitrobenzamide,molecular formula is C12H8ClN3O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1028-86-0.

Stage B: 2-(2-nitrophenyl)oxazolo[5,4-b]pyridine Using the procedure described in Example 1, but replacing 3-benzoylamino-2-chloropyridine by 3-(2-nitrobenzoylamino)-2-chloropyridine obtained in stage A. Yield: 77% Recrystallization solvent: ether/cyclohexane Melting point: 125 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1028-86-0, N-(2-Chloropyridin-3-yl)-2-nitrobenzamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Science et Organisation; US5077408; (1991); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 953780-42-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 953780-42-2, name is 5-Fluoro-6-methoxynicotinic acid. A new synthetic method of this compound is introduced below.

Triethylamine (267 mul), tert-butanol (230 mul), and DPPA(413 mul) were added to a toluene (5 ml) solution containing 5-fluoro-6-methoxynicotinic acid (275 mg), followed by reflux for 3 hours. Water was added to the reaction solution, followed by extraction with ethyl acetate. The resultant was washed with saturated saline and dried over anhydrous sodium sulfate. Subsequently, the solvent was distilled away under reduced pressure, the obtained residue was purified by silica gel chromatography (n-hexane : ethyl acetate = 10:1 to 3:1), and colorless oily matter of tert-butyl(5-fluoro-6-methoxypyridin-3-yl)carbamate (279 mg) was thus obtained. MS (ESI m/z): 243 (M+H) RT (min): 1.46

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,953780-42-2, its application will become more common.

Reference:
Patent; FUJIFILM Corporation; FUJIWARA, Hideyasu; SATO, Kimihiko; MIZUMOTO, Shinsuke; SATO, Yuichiro; KURIHARA, Hideki; KUBO, Yohei; NAKATA, Hiyoku; BABA, Yasutaka; TAMURA, Takashi; KUNIYOSHI, Hidenobu; HAGIWARA, Shinji; YAMAMOTO, Mari; (630 pag.)EP2589592; (2018); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem