Day: June 8, 2021

Related Products of 1200498-46-9 ,Some common heterocyclic compound, 1200498-46-9, molecular formula is C7H3FN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Dimethylformamide (10 muL, 0.14 mmol) and oxalyl chloride (119 muL, 1.38 mmol) is added to acetonitrile (3.7 mL) and stirred at room temperature for 10 minutes. 5-Cyano-3-fluoro-pyridine-2-carboxylic acid (213 mg, 1.28 mmol) is added and the mixture is stirred for another 10 minutes.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1200498-46-9, 5-Cyano-3-fluoropicolinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GREEN, Steven James; HEMBRE, Erik James; MERGOTT, Dustin James; SHI, Yuan; WATSON, Brian Morgan; WINNEROSKI, JR., Leonard Larry; US2014/371212; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1196155-38-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1196155-38-0, name is 2-Chloro-6-(trifluoromethyl)isonicotinonitrile, molecular formula is C7H2ClF3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a stirred solution of methyl 3,5-dihydroxybenzoate 2 (163 mg, 0.97 mmol) in DMF (10 mL) at RT, were added K2C03 (161 mg, 1.16 mmol) and 2-chloro-6- (trifluoromethyl)isonicotinonitrile 1 (200 mg, 0.97 mmol). The reaction mixture was stirred at RT for 16 h. The mixture was quenched with water (20 mL) and extracted with EtOAc (2 x 20 mL), and the combined organic extracts were washed with brine (10 mL), dried (Na2S04), filtered and concentrated. The residue was purified (silica gel; eluting 20-25percent EtOAc/hexanes) to afford compound 3 (110 mg, 34percent) as a white solid. 1H NMR (500MHz, CDC13): delta 7.59 (s, 1H), 7.41 – 7.44 (m, 2H), 7.36 (s, 1H), 6.90 (br s, 1H), 3.91 (s, 3H); LCMS Mass: 339.1 (M++l).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1196155-38-0, 2-Chloro-6-(trifluoromethyl)isonicotinonitrile.

Reference:
Patent; PHARMAKEA, INC.; ROWBOTTOM, Martin W.; HUTCHINSON, John Howard; CALDERON, Imelda; (202 pag.)WO2016/144703; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1480-65-5, Adding some certain compound to certain chemical reactions, such as: 1480-65-5, name is 5-Chloro-2-fluoropyridine,molecular formula is C5H3ClFN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1480-65-5.

To a suspension of cesium carbonate (3.76 g, 11.5 mmol) in DMF (20 mL) at room temperature was added 5-chloro-2-fluoropyridine (1.00 mL, 9.96 mmol) and benzylmercaptan (1.15 mL, 9.80 mmol). The reaction mixture was stirred at room temperature for 16 h and heated to 60 °C for 6 h. The reaction mixture was diluted with Et20. The organic phase was washed with water (2 x), brine and dried over MgS04. The filtrate was concentrated under reduced pressure and the residue was purified by flash column chromatography on silica gel ( 5percent to 10percent EtOAc in heptane) to give the title compound (2.33 g, 9.88 mmol, 101percento yield) as a colorless oil that was used without further purification in the next step. MS) m/z = 236.1 [M+H]+

According to the analysis of related databases, 1480-65-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AMGEN INC.; MINATTI, Ana Elena; LOW, Jonathan, D.; ALLEN, Jennifer, R.; AMEGADZIE, Albert; BROWN, James; FROHN, Michael, J.; GUZMAN-PEREZ, Angel; HARRINGTON, Paul, E.; LOPEZ, Patricia; MA, Vu Van; NISHIMURA, Nobuko; QIAN, Wenyuan; RUMFELT, Shannon; RZASA, Robert, M.; SHAM, Kelvin; SMITH, Adrian, L.; WHITE, Ryan; XUE, Qiufen; WO2014/138484; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 14150-94-8, name is 1-Methyl-3,5-dinitro-1H-pyridin-2-one. A new synthetic method of this compound is introduced below., Recommanded Product: 14150-94-8

General procedure: To a solution of the dinitropyridone 1 (50 mg, 0.25 mmol) in ethanol (10 mL), 4-phenyl-3-buten-2-one (4a) (36.5 mg, 0.25 mmol) and NH4OAc (578 mg, 7.5 mmol) were added, and the resultant mixture was heated at 65 C for 24 h. After removal of the solvent, the residue was washed with benzene (3 × 10 mL) to remove unreacted ketone 4a and treated with column chromatography on silica gel (eluent: hexane/ethyl acetate =95/5) to afford 5-nitro-2-(2-phenylethenyl)pyridine (5a) (41 mg, 0.18 mmol, 72%) as a yellow powder. The reactions of the dinitropyridone 1 with other ketones 4b-f or 10a-c were performed in a similar way.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 14150-94-8, 1-Methyl-3,5-dinitro-1H-pyridin-2-one.

Reference:
Article; Le, Song Thi; Asahara, Haruyasu; Nishiwaki, Nagatoshi; Chemistry Letters; vol. 44; 6; (2015); p. 776 – 778;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 13091-23-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 13091-23-1, name is 4-Chloro-3-nitropyridine. A new synthetic method of this compound is introduced below.

Ammonia gas (100 mL) was condensed into THF (300 mL) at -78C in a cardice/acetone bath. Potassium tert- butoxide (395 mmol, 44.25 g) was then added portion-wise with stirring. After 5 minutes, the cardice bath was lowered so only the bottom quarter of the flask was immersed and stirring was continued for a further 20 minutes. Concurrently, tert-butyl hydroperoxide (158 mmol, 26.3 mL) was added to a suspension of 4-chloro-3- nitropyridine (158 mmol, 25 g) in THF (100 mL) cooled in an ice/water bath. This mixture was stirred for 45 minutes then transferred to a dropping funnel and added drop-wise over 1.25 hours to the ammonia solution (0797) prepared above. The mixture was stirred for a further 3 hours then saturated aqueous ammonium chloride solution (35 mL) was added carefully. The mixture was allowed to warm to room temperature overnight allowing the ammonia to vent to atmosphere. The solvents were then removed under reduced pressure and the residue triturated with ice-cold saturated aqueous ammonium chloride solution (50 mL) . The resulting solid was collected by filtration, washed with ice-cold water (2 x 50 mL) then dried under suction prior to further drying by azeotroping with toluene (5 x 100 mL) then in a vacuum oven at 40C overnight to give the title compound as a brown solid (24.96 g, 90%) .

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13091-23-1, 4-Chloro-3-nitropyridine, and friends who are interested can also refer to it.

Reference:
Patent; ONO PHARMACEUTICAL CO., LTD.; SAITO, Tetsuji; HIGASHINO, Masato; KAWAHARADA, Soichi; LEWIS, Arwel; CHAMBERS, Mark Stuart; RAE, Alastair; HIRST, Kim Louise; HARTLEY, Charles David; WO2015/115673; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.159307-02-5, name is 6-Acetylpicolinonitrile, molecular formula is C8H6N2O, molecular weight is 146.15, as common compound, the synthetic route is as follows.Application In Synthesis of 6-Acetylpicolinonitrile

Compound 4b:to 100 ml by adding three-necked bottle of 2-cyano-6-acetyl-pyridine (3.00g, 20 . 53mmol), 2,6-dimethyl aniline (2.74g, 22 . 58mmol), the toluene sulphonic acid monohydrate (195 mg, 1 . 03mmol), solvent toluene and 50 ml, reflux device installed, heating reaction refluxing 48h. Cooling to room temperature, vacuum concentration, rapid column chromatography purification (ethyl acetate: petroleum ether = 1:20), to get the yellow oily matter (5.04g, 96%),

At the same time, in my other blogs, there are other synthetic methods of this type of compound,159307-02-5, 6-Acetylpicolinonitrile, and friends who are interested can also refer to it.

Reference:
Patent; Shanghai Institute of Organic Chemistry; Huang, Zheng; Zuo, Ziqing; Zhang, Lei; (50 pag.)CN105294667; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.105752-11-2, name is 3-Amino-4-iodopyridine, molecular formula is C5H5IN2, molecular weight is 220.0111, as common compound, the synthetic route is as follows.name: 3-Amino-4-iodopyridine

Step 1: 4-[(2-fluorophenyl)ethvnyl]pyridin-3-amineTo a solution of 3-amino-4-iodopyridine in Dioxane/DMF (1 :1, 0.7M) were sequentially added NEt3 (5eq.), CuI (0.04 eq.), trans-bis(triphenylphosphine) palladium(II) chloride (0.02 eq.) and l-ethynyl-2-fluorobenzene (2 eq.). After heating for 1 h at 70 0C, water was added and the mixture was extracted with Et2O. The combined organic layers were washed with brine, dried over Na2SO4, filtered and the solvent was evaporated in vacuo. The residue was purified by chromatography on silica gel, eluting with PE/EtOAc (50:50), affording the title compound(80%) as a solid. 1H NMR (400 MHz, OMSO-d6 + TFA, 300K) delta, 7.26-7.33 (dd, 2H, J = 7.6 Hz, J= 8 Hz), 7.52-7.53 (m, IH), 7.78 (d, IH, J= 8 Hz), 7.83 (t, IH, J= 6.4 Hz), 7.7 (d, IH, J= 5.6 Hz), 8.21 (s, IH); MS (ES+) m/z 213 (M +H)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,105752-11-2, 3-Amino-4-iodopyridine, and friends who are interested can also refer to it.

Reference:
Patent; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.; NARJES, Frank; HABERMANN, Jorg; COLARUSSO, Stefania; WO2010/115901; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 90902-84-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 90902-84-4, name is 2,5-Dibromopyridin-3-amine, molecular formula is C5H4Br2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(c) 1,1-Dimethylethyl (7-bromo-2-oxo-l,2,3,4-tetrahydro-l,5-naphthyridin-3- yl)carbamate; Zinc powder (0.934 g, 14.28 mmol) and iodine (0.054 g, 0.214 mmol) were heated in an evacuated flask which was then flushed with nitrogen 3 times. Methyl N- {[(l,l-dimethylethyl)oxy]carbonyl}-3-iodo-D-alaninate (2.35 g, 7.14 mmol, Aldrich Chemicals ) was dissolved in dry DMF (11.74 mL) and transferred via syringe to the reaction mixture which was previously cooled to 00C (reaction complete after 1.5h). The ice bath was removed and 2,5-dibromo-3-pyridinamine (2.392 g, 9.50 mmol) was added followed by bis (triphenylphosphine)palladium(II) chloride (0.251 g, 0.357 mmol) and the mixture heated at 40 0C for 14h. The mixture was cooled down and filtered through Celite, washing with EtOAc. Solvent was removed in vacuum. The mixture was redisolved in DMF (10 mL) and potassium carbonate (1.283 g, 9.28 mmol) was added. The resulting mixture was stirred at 80 0C for 6h. The mixture was concentrated and diluted with EtOAc, washed with water and brine and dried over Mg2SO4. Solvent was removed and the mixture chromatographed on silica eluting with 0-100% EtOAc :hexane to give the title compound (1.8 g, 5.26 mmol, 73.7 % yield) as light yellow solid. MS (ES+) m/z 343(MH+).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 90902-84-4, 2,5-Dibromopyridin-3-amine.

Reference:
Patent; GLAXO GROUP LIMITED; WO2008/128961; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 918516-27-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.918516-27-5, name is 5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridine, molecular formula is C13H9ClN2, molecular weight is 228.68, as common compound, the synthetic route is as follows.

To a suspension of 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine (6b) (100 mg, 0.44 mmol) and N-(2,4-difluoro-3-formylphenyl)propane-1-sulfonamide (5) (139 mg, 0.53 mmol) in methanol (7.0 mL) was added potassium hydroxide (197 mg, 3.5 mmol). The reaction mixture was stirred at room temperature for 3 d and then evaporated to dryness. The crude reaction mixture was diluted with water (5.0 mL) and the pH adjusted to 7 with 4.0 N hydrochloric acid (10 mL). The resulting mixture was then diluted with water (25 mL) and extracted with ethyl acetate (3 x 20 mL). The combined organic layers were dried over sodium sulphate and evaporated in vacuo to give a crude solid (as a 2:1 mixture of the -OMe and free-OH 7b).

The chemical industry reduces the impact on the environment during synthesis 918516-27-5, I believe this compound will play a more active role in future production and life.

Reference:
Article; Buck, Jason R.; Saleh, Sam; Imam Uddin, Md.; Manning, H. Charles; Tetrahedron Letters; vol. 53; 32; (2012); p. 4161 – 4165;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.84249-14-9, name is 2-Amino-4-bromopyridine, molecular formula is C5H5BrN2, molecular weight is 173.0106, as common compound, the synthetic route is as follows.Quality Control of 2-Amino-4-bromopyridine

To a solution of potassium 2-chloro-3 -ethoxy-3 -oxoprop-l-en-l-olate (13.0 g, 68.9 mmol) and 4-bromopyridin-2-amine (3.00 g, 17.3 mmol) in ethanol (60 mL) was added cone. H2SO4 (2 mL). The reaction mixture was stirred at 90 C for 18 h and concentrated in vacuo. The residue was adjusted to pH = 10 with a saturated NaHCO, aqueous solution, and extracted with EtOAc (200 mL x 3). The combined organic phases were washed with brine (100 mL), dried over anhydrous Na2S04, and concentrated in vacuo. The residue was purified by a silica gel column chromatography (EtOAc/PE (v/v) = 1/4) to give the title compound as a white solid (4.6 g, 99%).MS (ESI, pos. ion) m/z: 269.1 [M+H]+;1H NMR (400 MHz, CDCb): d (ppm) 9.17 (d, J= 7.3 Hz, 1H), 8.26 (s, 1H), 7.92 (d, 7= 1.1 Hz, 1H), 7.14 (dd, J= 7.3, 1.6 Hz, 1H), 4.41 (q, J= 7.1 Hz, 2H), 1.42 (t, J= 7.1 Hz, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,84249-14-9, 2-Amino-4-bromopyridine, and friends who are interested can also refer to it.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; XI, Ning; LI, Minxiong; PENG, Ju; LI, Xiaobo; ZHANG, Tao; HU, Haiyang; CHEN, Wuhong; BAI, Changlin; KE, Donghua; CHEN, Peng; (281 pag.)WO2019/99311; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem